SCHEMBL8327082

SCHEMBL8327082

CC(C)=CCC[C@H](C)[C@@H](C)CN

nearest known ligand 0.48

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
ALOX15 P16050 3/20 0.48
ALDH1A1 P00352 2/20 0.48
TSHR P16473 1/20 0.44
SRC P12931 1/20 0.35
KMT2A Q03164 1/20 0.34
SQLE Q14534 1/20 0.34
USP2 O75604 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
GLA P06280 1/20 0.33
HPGD P15428 1/20 0.33
POLB P06746 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8967234 0.79 ALOX15 (0.50) ALOX15ALDH1A1TSHRSRCKMT2A
SCHEMBL22111411 0.79 ALOX15 (0.56) ALOX15ALDH1A1TSHRSRCKMT2A
SCHEMBL22111231 0.79 ALOX15 (0.56) ALOX15ALDH1A1TSHRSRCKMT2A
SCHEMBL28695353 0.79 ALOX15 (0.61) ALOX15ALDH1A1TSHRSRCUSP2
SCHEMBL28695355 0.79 ALOX15 (0.61) ALOX15ALDH1A1TSHRSRCUSP2
SCHEMBL8468877 0.79 ALOX15 (0.56) ALOX15ALDH1A1TSHRSRCKMT2A
SCHEMBL11868741 0.76 ALOX15 (0.52) ALOX15ALDH1A1TSHRSRCKMT2A
SCHEMBL27017839 0.74 ALOX15 (0.55) ALOX15ALDH1A1TSHRKMT2ASQLE
SCHEMBL27017811 0.74 ALOX15 (0.45) ALOX15ALDH1A1TSHRSRCKMT2A
SCHEMBL1372187 0.73

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0789571-A4 CYCLIC AMIDINE ANALOGS AS INHIBITORS OF NITRIC OXIDE SYNTHASE MERCK & CO INC (US) 1999-04-14 EP disclosed
EP-0789571-A1 CYCLIC AMIDINE ANALOGS AS INHIBITORS OF NITRIC OXIDE SYNTHASE Merck & Co., Inc. (US) 1997-08-20 EP disclosed
US-5629322-A TREATMENT OF NEURODEGENERATIVE DISORDERS, DISORDERS OF GASTROINTESTINAL MOTILITY AND INFLAMMATION MERCK & CO., INC. (US) 1997-05-13 US disclosed
WO-1996014844-A1 CYCLIC AMIDINE ANALOGS AS INHIBITORS OF NITRIC OXIDE SYNTHASE MERCK & CO., INC. (US) 1996-05-23 WO disclosed