Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.36 |
| ▸ | SQLE | Q14534 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22111411 | 1.00 | ALOX15 (0.56) | ALOX15ALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL22111231 | 1.00 | ALOX15 (0.56) | ALOX15ALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL27017839 | 0.80 | ALOX15 (0.55) | ALOX15ALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL30312269 | 0.80 | ALDH1A1 (0.36) | ALOX15ALDH1A1TSHR | |
| SCHEMBL8327082 | 0.79 | ALOX15 (0.48) | ALOX15ALDH1A1TSHRKMT2ASRC | |
| SCHEMBL11868741 | 0.78 | ALOX15 (0.52) | ALOX15ALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL17967786 | 0.78 | ALOX15 (0.71) | ALOX15ALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL811437 | 0.78 | ALOX15 (0.71) | ALOX15ALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL8967234 | 0.76 | ALOX15 (0.50) | ALOX15ALDH1A1TSHRKMT2AMEN1 | |
| SCHEMBL27017811 | 0.76 | ALOX15 (0.45) | ALOX15ALDH1A1TSHRKMT2ASRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0789571-A4 | CYCLIC AMIDINE ANALOGS AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO INC (US) | 1999-04-14 | — | — | EP | disclosed |
| EP-0789571-A1 | CYCLIC AMIDINE ANALOGS AS INHIBITORS OF NITRIC OXIDE SYNTHASE | Merck & Co., Inc. (US) | 1997-08-20 | — | — | EP | disclosed |
| US-5629322-A | TREATMENT OF NEURODEGENERATIVE DISORDERS, DISORDERS OF GASTROINTESTINAL MOTILITY AND INFLAMMATION | MERCK & CO., INC. (US) | 1997-05-13 | — | — | US | disclosed |
| WO-1996014844-A1 | CYCLIC AMIDINE ANALOGS AS INHIBITORS OF NITRIC OXIDE SYNTHASE | MERCK & CO., INC. (US) | 1996-05-23 | — | — | WO | disclosed |