Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 9/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | GFER | P55789 | 3/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.57 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | HTT | P42858 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325536 | 0.95 | MAPT (0.68) | MAPTMEN1KMT2AGFERMAPK1 | |
| SCHEMBL8327503 | 0.89 | L3MBTL1 (0.61) | MAPTMEN1KMT2AGFERMAPK1 | |
| SCHEMBL12182367 | 0.83 | L3MBTL1 (0.68) | MAPTMEN1KMT2AGFERMAPK1 | |
| SCHEMBL9987782 | 0.82 | MAPT (0.67) | MAPTMEN1KMT2AGFERMAPK1 | |
| SCHEMBL30862678 | 0.81 | ME2 (0.63) | MAPTMAPK1ALDH1A1LMNAPOLB | |
| SCHEMBL17260630 | 0.79 | MAPT (0.67) | MAPTMEN1KMT2AGFERMAPK1 | |
| SCHEMBL945994 | 0.79 | L3MBTL1 (0.66) | MAPTMEN1KMT2AGFERMAPK1 | |
| SCHEMBL5281130 | 0.78 | MAPT (0.61) | MAPTMEN1KMT2AGFERMAPK1 | |
| SCHEMBL2824010 | 0.78 | MEN1 (0.72) | MAPTMEN1KMT2AGFERMAPK1 | |
| SCHEMBL1374155 | 0.78 | ALDH1A1 (0.59) | MAPTMEN1KMT2AGFERMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1592426-B1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2007-12-19 | — | — | EP | disclosed |
| WO-2004069256-A1 | 2-CYANOPYRROLOPYRIMIDINES AND PHARMACEUTICAL USES THEREOF | NOVARTIS AG (CH) | 2004-08-19 | — | — | WO | disclosed |