Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | DNM1 | Q05193 | 9/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2339806 | 1.00 | LMNA (0.41) | LMNADNM1TSHRTHRBHTT | |
| SCHEMBL15310044 | 1.00 | LMNA (0.41) | LMNADNM1TSHRTHRBHTT | |
| Bromide SCHEMBL21253208 | 0.98 | DNM1 (0.42) | LMNADNM1TSHRTHRBHTT | |
| Hydrochloric Acid SCHEMBL114418 | 0.98 | DNM1 (0.42) | LMNADNM1TSHRTHRBHTT | |
| Bromide SCHEMBL8402695 | 0.98 | DNM1 (0.42) | LMNADNM1TSHRTHRBHTT | |
| Hydrochloric Acid SCHEMBL9465437 | 0.98 | DNM1 (0.42) | LMNADNM1TSHRTHRBHTT | |
| Bromide SCHEMBL21253076 | 0.98 | DNM1 (0.42) | LMNADNM1TSHRTHRBHTT | |
| Bromide SCHEMBL21253115 | 0.98 | DNM1 (0.42) | LMNADNM1TSHRTHRBHTT | |
| Bromide SCHEMBL21247653 | 0.98 | DNM1 (0.42) | LMNADNM1TSHRTHRBHTT | |
| Hydrochloric Acid SCHEMBL21253135 | 0.98 | DNM1 (0.42) | LMNADNM1TSHRTHRBHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5929094-A | NOVEL 3-((SUBSTITUTED) HETEROCYCLE),6-(SUBSTITUTED PHENYL)-1-OXASPIRO(4.4)NONANE DERIVATIVES; ANTAGONIZING THE EFFECT OF SUBSTANCE P BY ADMINISTERING TO BLOCK NEUROKININ-1 RECEPTORS; TREATING INFLAMMATION, MIGRAINE, EMESIS AND ASTHMA | MERCK & CO., INC. (US) | 1999-07-27 | — | — | US | claimed |
| US-5929094-A | NOVEL 3-((SUBSTITUTED) HETEROCYCLE),6-(SUBSTITUTED PHENYL)-1-OXASPIRO(4.4)NONANE DERIVATIVES; ANTAGONIZING THE EFFECT OF SUBSTANCE P BY ADMINISTERING TO BLOCK NEUROKININ-1 RECEPTORS; TREATING INFLAMMATION, MIGRAINE, EMESIS AND ASTHMA | MERCK & CO., INC. (US) | 1999-07-27 | — | — | US | disclosed |
| WO-1998017276-A1 | HETEROARYL SPIROETHERCYCLOALKYL TACHYKININ RECEPTOR ANTAGONISTS | MERCK & CO., INC. (US) | 1998-04-30 | — | — | WO | disclosed |