Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 6/20 | 0.49 |
| ▸ | SPHK1 | Q9NYA1 | 6/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | GBA1 | P04062 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CRHBP | P24387 | 1/20 | 0.42 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9131967 | 0.95 | SPHK1 (0.53) | SPHK2SPHK1ALDH1A1GBA1 | |
| SCHEMBL9134554 | 0.95 | SPHK1 (0.53) | SPHK2SPHK1ALDH1A1GBA1 | |
| SCHEMBL10355476 | 0.95 | SPHK1 (0.53) | SPHK2SPHK1ALDH1A1GBA1 | |
| SCHEMBL10462905 | 0.86 | SPHK2 (0.50) | SPHK2SPHK1ALDH1A1MAPK1GBA1 | |
| SCHEMBL1713938 | 0.84 | OPRD1 (0.52) | SPHK2SPHK1ALDH1A1 | |
| SCHEMBL6335780 | 0.84 | OPRD1 (0.52) | SPHK2SPHK1ALDH1A1 | |
| SCHEMBL9148606 | 0.83 | SPHK2 (0.51) | SPHK2SPHK1GBA1 | |
| SCHEMBL9148614 | 0.83 | SPHK2 (0.51) | SPHK2SPHK1GBA1 | |
| SCHEMBL24200047 | 0.83 | OPRD1 (0.51) | SPHK2SPHK1 | |
| SCHEMBL5192834 | 0.81 | SPHK2 (0.47) | SPHK2SPHK1ALDH1A1MAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0760368-B1 | PYRIMIDINE DERIVATIVES | NISSHIN FLOUR MILLING CO (JP) | 1999-07-28 | — | — | EP | disclosed |
| US-5736550-A | TREATMENT OF GASTROINTESTINAL TRACT DISORDERS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-04-07 | — | — | US | disclosed |
| EP-0760368-A1 | NOVEL PYRIMIDINE DERIVATIVE | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-03-05 | — | — | EP | disclosed |