Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SPHK2 | Q9NRA0 | 1/20 | 0.47 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5191096 | 0.86 | ALDH1A1 (0.46) | ALDH1A1SMN1; SMN2OPRD1MAPK1 | |
| SCHEMBL5195543 | 0.86 | ALDH1A1 (0.57) | SPHK2SPHK1ALDH1A1SMN1; SMN2OPRD1 | |
| SCHEMBL5195704 | 0.83 | SPHK2 (0.52) | SPHK2ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL8325845 | 0.83 | SPHK2 (0.45) | SPHK2SPHK1ALDH1A1SMN1; SMN2 | |
| SCHEMBL14822325 | 0.82 | OPRD1 (0.51) | SPHK2SPHK1OPRD1 | |
| SCHEMBL8327242 | 0.81 | SPHK2 (0.49) | SPHK2SPHK1ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL8326443 | 0.81 | KDM4E (0.55) | SPHK2SPHK1ALDH1A1SMN1; SMN2OPRD1 | |
| SCHEMBL10462905 | 0.80 | SPHK2 (0.50) | SPHK2SPHK1ALDH1A1SMN1; SMN2MAPK1 | |
| SCHEMBL5190927 | 0.80 | KDM4E (0.50) | SPHK2SPHK1ALDH1A1SMN1; SMN2OPRD1 | |
| SCHEMBL5193942 | 0.79 | FAAH (0.46) | SPHK2SPHK1ALDH1A1SMN1; SMN2MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0968206-B8 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX INC (US) | 2007-01-24 | — | — | EP | disclosed |
| EP-0968206-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 2000-01-05 | — | — | EP | disclosed |
| WO-1998037079-A1 | N-HETEROCYCLIC DERIVATIVES AS NOS INHIBITORS | BERLEX LABORATORIES, INC. (US) | 1998-08-27 | — | — | WO | disclosed |