Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.80 |
| ▸ | TSHR | P16473 | 3/20 | 0.80 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.68 |
| ▸ | NPC1 | O15118 | 1/20 | 0.66 |
| ▸ | POLB | P06746 | 4/20 | 0.66 |
| ▸ | ALDH3A1 | P30838 | 4/20 | 0.66 |
| ▸ | NOD1 | Q9Y239 | 1/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.65 |
| ▸ | GAA | P10253 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | PKM | P14618 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 1/20 | 0.54 |
| ▸ | USP2 | O75604 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8330999 | 0.86 | HTT (0.67) | HTTTSHRKMT2ANPC1POLB | |
| SCHEMBL17960655 | 0.83 | HTT (0.69) | HTTTSHRKMT2ANPC1POLB | |
| SCHEMBL8329551 | 0.80 | ALDH3A1 (1.00) | HTTTSHRKMT2ANPC1POLB | |
| SCHEMBL8324963 | 0.75 | HTT (0.55) | HTTTSHRKMT2ANPC1POLB | |
| SCHEMBL3470648 | 0.75 | ALOX5 (0.75) | HTTTSHRKMT2ANPC1POLB | |
| SCHEMBL19848205 | 0.74 | HTT (0.69) | HTTTSHRKMT2ANPC1POLB | |
| SCHEMBL19911331 | 0.74 | HTT (0.69) | HTTTSHRKMT2ANPC1POLB | |
| SCHEMBL422055 | 0.72 | ALDH3A1 (0.77) | HTTTSHRKMT2APOLBALDH3A1 | |
| SCHEMBL7100805 | 0.72 | ALDH3A1 (0.61) | HTTTSHRKMT2APOLBALDH3A1 | |
| SCHEMBL14919981 | 0.71 | GAA (0.59) | HTTTSHRKMT2ANPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0869787-A4 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORP (US) | 1999-03-24 | — | — | EP | disclosed |
| EP-0869787-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1998-10-14 | — | — | EP | disclosed |
| WO-1997024119-A1 | VITRONECTIN RECEPTOR ANTAGONISTS | SMITHKLINE BEECHAM CORPORATION (US) | 1997-07-10 | — | — | WO | disclosed |