SCHEMBL8327261

SCHEMBL8327261

O=C(N1CCOCC1)C1(c2ccccc2)CC[N]CC1

nearest known ligand 0.74

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 1/20 0.74
ALDH1A1 P00352 6/20 0.66
TSHR P16473 2/20 0.66
LMNA P02545 1/20 0.66
NPSR1 Q6W5P4 1/20 0.66
HSD11B1 P28845 4/20 0.59
MEN1 O00255 3/20 0.56
KMT2A Q03164 3/20 0.56
CYP3A4 P08684 2/20 0.53
CYP2C19 P33261 2/20 0.53
SLC6A2 P23975 1/20 0.49
SLC6A4 P31645 1/20 0.49
SLC6A3 Q01959 1/20 0.49
CYP1A2 P05177 1/20 0.46
CYP2D6 P10635 1/20 0.46
CYP2C9 P11712 1/20 0.46
PKM P14618 1/20 0.46
PRCP P42785 1/20 0.46
TMEM97 Q5BJF2 1/20 0.46
SIGMAR1 Q99720 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8919562 0.87 HSD11B1 (0.79) SMN1; SMN2ALDH1A1TSHRLMNANPSR1
SCHEMBL8331178 0.85 HSD11B1 (0.79) SMN1; SMN2ALDH1A1TSHRLMNANPSR1
SCHEMBL5371532 0.84 SMN1; SMN2 (0.76) SMN1; SMN2ALDH1A1TSHRLMNANPSR1
SCHEMBL373284 0.83 SMN1; SMN2 (0.74) SMN1; SMN2ALDH1A1TSHRLMNANPSR1
Hydrochloric Acid SCHEMBL6162211 0.82 SMN1; SMN2 (0.72) SMN1; SMN2ALDH1A1TSHRLMNANPSR1
SCHEMBL8434436 0.80 SMN1; SMN2 (0.69) SMN1; SMN2ALDH1A1TSHRLMNANPSR1
SCHEMBL8257825 0.80 SMN1; SMN2 (0.69) SMN1; SMN2ALDH1A1TSHRLMNANPSR1
SCHEMBL18712980 0.77 ALDH1A1 (0.74) SMN1; SMN2ALDH1A1TSHRLMNANPSR1
SCHEMBL18390066 0.77 ALDH1A1 (0.74) SMN1; SMN2ALDH1A1TSHRLMNANPSR1
SCHEMBL2269271 0.76 SMN1; SMN2 (0.63) SMN1; SMN2ALDH1A1TSHRLMNANPSR1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5925642-A ANTITUMOR, ANTIMETASTASIS AGENTS; DRUG RESISTANCE MODULATORS; SYNERGISTIC MIXTURES WITH ANTIBIOTICS AND CYTOSTATIC AGENTS; SIDE EFFECT REDUCTION BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1999-07-20 US disclosed
EP-0808303-A1 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST ZENECA LIMITED (GB) 1997-11-26 EP disclosed
US-5668131-A CONTROLLING HELICOBACTER BACTERIA BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1997-09-16 US disclosed
WO-1996024582-A1 5-(4-SUBST.-PIPERIDINYL-1)-3-ARYL-PENTANOIC ACID DERIVATIVES AS TACHYKININ RECEPTOR ANTAGONIST ZENECA LIMITED (GB) 1996-08-15 WO disclosed
WO-1996000224-A1 4-S- AND N-SUBSTITUTED 6-ALKYLPYRIDINES FOR CONTROLLING HELICOBACTER BACTERIA BYK GULDEN LOMBERG CHEMISCHE FABRIK GMBH (DE) 1996-01-04 WO disclosed