SCHEMBL8327318

SCHEMBL8327318

CCn1nc(C(F)(F)F)c(N)c1Cl

nearest known ligand 0.38

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 1/20 0.38
RECQL P46063 1/20 0.38
LMNA P02545 1/20 0.30
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8323814 0.79 KDM4E (0.39) KDM4ERECQLLMNAPOLB
SCHEMBL8325471 0.75 HPGD (0.33) KDM4ERECQL
SCHEMBL8322237 0.75 KDM4E (0.43) KDM4ERECQLLMNAPOLB
SCHEMBL939241 0.74 KDM4E (0.35) KDM4ERECQL
SCHEMBL8323455 0.73 KDM4E (0.40) KDM4ERECQLLMNAPOLB
SCHEMBL16809896 0.72 KDM4E (0.36) KDM4ERECQLLMNAPOLB
SCHEMBL31081858 0.71 ALDH1A1 (0.36) KDM4ERECQLLMNAPOLB
SCHEMBL16200178 0.70 KDM4E (0.44) KDM4ERECQL
SCHEMBL5284294 0.69 GABRA2 (0.33) KDM4ERECQL
SCHEMBL21721680 0.68 BRD9 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0789698-B1 N-(1-ETHYL-4-PYRAZOLYL)TRIAZOLOAZINESULFONAMIDE HERBICIDES DOW AGROSCIENCES LLC (US) 1999-07-07 EP disclosed
US-5763359-A N-(1-ethyl-4-pyrazolyl)triazoloazinesulfonamide herbicides DOW AGROSCIENCES LLC (US) 1998-06-09 US disclosed
EP-0789698-A1 N-(1-ETHYL-4-PYRAZOLYL)TRIAZOLOAZINESULFONAMIDE HERBICIDES DOWELANCO (US) 1997-08-20 EP disclosed
WO-1997008172-A1 N-(1-ETHYL-4-PYRAZOLYL)TRIAZOLOAZINESULFONAMIDE HERBICIDES DOWELANCO (US) 1997-03-06 WO disclosed