Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDYL2 | Q8N8U2 | 3/20 | 0.53 |
| ▸ | CDYL | Q9Y232 | 3/20 | 0.53 |
| ▸ | CDY1; CDY1B | Q9Y6F8 | 3/20 | 0.53 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.44 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.44 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8468988 | 0.88 | NPC1 (0.51) | LMNANPC1RAB9AMAPTKDM4E | |
| SCHEMBL8329544 | 0.84 | KMT2A (0.45) | LMNAHTTL3MBTL1SMN1; SMN2RAB9A | |
| Hydrochloric Acid SCHEMBL8329003 | 0.83 | KMT2A (0.44) | LMNAHTTL3MBTL1SMN1; SMN2RAB9A | |
| SCHEMBL8329803 | 0.80 | PKM (0.45) | MAPK1LMNATDP1L3MBTL1SMN1; SMN2 | |
| SCHEMBL8328067 | 0.79 | RXFP1 (0.45) | CA12CA9CA1LMNAHTT | |
| SCHEMBL8328087 | 0.78 | GSK3B (0.47) | MAPK1LMNASMN1; SMN2RAB9AMAPT | |
| SCHEMBL15030495 | 0.78 | CDYL2 (0.54) | CDYL2CDYLCDY1; CDY1BCA12CA9 | |
| SCHEMBL8327469 | 0.78 | HTT (0.42) | MAPK1HTTTDP1L3MBTL1NPC1 | |
| SCHEMBL8326356 | 0.78 | POLB (0.41) | CA12CA9CA1LMNARAB9A | |
| SCHEMBL8322914 | 0.76 | NPC1 (0.46) | CDYL2CDYLCDY1; CDY1BMAPK1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509974-B1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | ASTRA AB (SE) | 1999-01-13 | — | — | EP | disclosed |
| US-5439917-A | Phenyl-pyrrolo(2,3-b)pyridine antisecretory agent of gastric acid; adenosine triphosphatase enzyme inhibitor | AKTIEBOLAGET ASTRA (SE) | 1995-08-08 | — | — | US | disclosed |
| EP-0580616-A1 | NEW ACTIVE COMPOUNDS | Astra Aktiebolag (SE) | 1994-02-02 | — | — | EP | disclosed |
| EP-0509974-A1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | Astra Aktiebolag (SE) | 1992-10-21 | — | — | EP | disclosed |
| WO-1992017477-A1 | NEW ACTIVE COMPOUNDS | AKTIEBOLAGET ASTRA (SE) | 1992-10-15 | — | — | WO | disclosed |