Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.46 |
| ▸ | MGAM | O43451 | 2/20 | 0.46 |
| ▸ | AMY1A | P0DUB6 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | SI | P14410 | 2/20 | 0.46 |
| ▸ | MGAM2 | Q2M2H8 | 2/20 | 0.46 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.43 |
| ▸ | CTSD | P07339 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | SRC | P12931 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327490 | 0.88 | CDYL2 (0.53) | NPC1RAB9AMAPTKDM4ETSHR | |
| SCHEMBL8329803 | 0.87 | PKM (0.45) | NPC1RAB9AMGAMAMY1AGAA | |
| SCHEMBL8328067 | 0.86 | RXFP1 (0.45) | NPC1RAB9AMAPTKDM4EALDH1A1 | |
| SCHEMBL8329544 | 0.86 | KMT2A (0.45) | RAB9AMGAMAMY1AGAASI | |
| SCHEMBL8328087 | 0.85 | GSK3B (0.47) | RAB9AMGAMAMY1AGAASI | |
| Hydrochloric Acid SCHEMBL8329003 | 0.85 | KMT2A (0.44) | RAB9AMGAMAMY1AGAASI | |
| SCHEMBL8322914 | 0.83 | NPC1 (0.46) | NPC1RAB9AMGAMAMY1AGAA | |
| SCHEMBL8326356 | 0.82 | POLB (0.41) | RAB9AGAALMNAGSK3B | |
| SCHEMBL8327469 | 0.80 | HTT (0.42) | NPC1RAB9AKDM4EALDH1A1CTSD | |
| SCHEMBL8328383 | 0.79 | FLT4 (0.43) | NPC1RAB9AMGAMAMY1AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0509974-B1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | ASTRA AB (SE) | 1999-01-13 | — | — | EP | disclosed |
| US-5439917-A | Phenyl-pyrrolo(2,3-b)pyridine antisecretory agent of gastric acid; adenosine triphosphatase enzyme inhibitor | AKTIEBOLAGET ASTRA (SE) | 1995-08-08 | — | — | US | disclosed |
| EP-0509974-A1 | Pyrrolo[2,3-b]pyridines having therapeutic activity and a process for the preparation thereof | Astra Aktiebolag (SE) | 1992-10-21 | — | — | EP | disclosed |