SCHEMBL8327563

SCHEMBL8327563

C=CCOc1ccc2cc(C(=O)O)ccc2c1

nearest known ligand 0.71

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 3/20 0.56
FFAR1 O14842 1/20 0.53
CA12 O43570 4/20 0.52
CA1 P00915 4/20 0.52
CA9 Q16790 4/20 0.52
NPC1 O15118 3/20 0.52
RAB9A P51151 3/20 0.52
ALDH1A1 P00352 1/20 0.50
L3MBTL1 Q9Y468 1/20 0.50
MAPT P10636 3/20 0.48
HTT P42858 1/20 0.48
MRGPRX4 Q96LA9 1/20 0.48
SMN1; SMN2 Q16637 2/20 0.46
POLB P06746 2/20 0.46
MEN1 O00255 1/20 0.45
LMNA P02545 1/20 0.45
KMT2A Q03164 1/20 0.45
PKM P14618 1/20 0.45
ADRA2A P08913 1/20 0.44
ADRA2B P18089 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6956443 0.97 KDM4E (0.53) KDM4EFFAR1CA12CA1CA9
SCHEMBL1489146 0.84 ALDH1A1 (0.67) FFAR1CA12CA1CA9NPC1
SCHEMBL15927541 0.84 CA12 (0.50) CA12CA1CA9NPC1RAB9A
SCHEMBL10841671 0.83 CHRNB2 (0.50) KDM4ECA12CA1CA9NPC1
SCHEMBL26041373 0.83 CA1 (0.49) CA12CA1CA9NPC1RAB9A
SCHEMBL8972612 0.83 ALDH1A1 (0.70) KDM4EALDH1A1L3MBTL1MAPTHTT
Benzene SCHEMBL28158854 0.83 ALDH1A1 (0.65) KDM4EFFAR1CA12CA1CA9
Hydrochloric Acid SCHEMBL711176 0.83 ALDH1A1 (0.65) FFAR1CA12CA1CA9NPC1
SCHEMBL3825460 0.82 CA12 (0.64) CA12CA1CA9NPC1RAB9A
SCHEMBL29784242 0.82 NPC1 (0.67) KDM4EFFAR1NPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5900145-A CROSSLINKED POLYSILOXANE LAYER HAVING AN AROMATIC LIQUID CRYSTAL SIDECHAIN INCLUDING A 2,6-NAPHTHALENE OR 4,4'-DIPHENYLENE GROUP; SEPARATION OF ISOMERS OF AROMATIC HYDROCARBONS, HALOGENATED AROMATIC TOXIC HYDROCARBONS J & K ENVIRONMENTAL LTD. (CA) 1999-05-04 US disclosed
US-5495037-A MESOGENIC SIDE CHAINS NATIONAL SCIENCE COUNCIL (TW) 1996-02-27 US disclosed
EP-0332409-B1 Novel substituted naphthalene compounds and liquid crystal compositions containing same MITSUI PETROCHEMICAL IND (JP) 1995-05-24 EP disclosed
EP-0422996-B1 Liquid crystal compound SHOWA SHELL SEKIYU (JP) 1995-04-12 EP disclosed
US-5328641-A Naphthalene ester derivatives with trifluoromethyl groups SHOWA SHELL SEKIYU KABUSHIKI KAISHA 1994-07-12 US disclosed
US-5207947-A Trifluoroalkyl diaryl triesters; antiferroelectricity; electrooptics SHOWA SHELL SEKIYU KABUSHIKI KAISHA (JP) 1993-05-04 US disclosed
US-5072021-A Liquid crystals MITSUI TOATSU CHEMICALS, INC. (JP) 1991-12-10 US disclosed
US-5053164-A For high speed switching MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1991-10-01 US disclosed
EP-0422996-A2 Liquid crystal compound Showa Shell Sekiyu Kabushiki Kaisha (JP) 1991-04-17 EP disclosed
US-4943651-A Novel substitued naphthalene compounds and liquid crystal compositions containing same MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1990-07-24 US disclosed
EP-0332409-A2 Novel substituted naphthalene compounds and liquid crystal compositions containing same MITSUI PETROCHEMICAL INDUSTRIES, LTD. (JP) 1989-09-13 EP disclosed