Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | ACHE | P22303 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 3/20 | 0.38 |
| ▸ | NFE2L2 | Q16236 | 3/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 1/20 | 0.37 |
| ▸ | MIF | P14174 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.36 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2093738 | 0.89 | MIF (0.43) | LMNATSHRMIFKDM4E | |
| SCHEMBL17923689 | 0.84 | LMNA (0.53) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| SCHEMBL12199145 | 0.84 | LMNA (0.53) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| SCHEMBL8324324 | 0.82 | ACP3 (0.46) | LMNATSHRALOX12ACHENPSR1 | |
| SCHEMBL7864100 | 0.81 | LMNA (0.50) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| SCHEMBL4068746 | 0.81 | LMNA (0.50) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| SCHEMBL8326598 | 0.81 | NPC1 (0.42) | LMNASMN1; SMN2MEN1KMT2ANPSR1 | |
| SCHEMBL13888777 | 0.78 | LMNA (0.48) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| SCHEMBL15617630 | 0.78 | LMNA (0.46) | LMNATSHRALOX12ACHESMN1; SMN2 | |
| SCHEMBL8323074 | 0.78 | PBRM1 (0.54) | LMNAL3MBTL1MEN1KMT2ANPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |