SCHEMBL8328140

SCHEMBL8328140

CS(=O)(=O)c1ccc(N=[N])cc1

nearest known ligand 0.50

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
ENPP2 Q13822 2/20 0.50
PTGS2 P35354 9/20 0.42
MAPT P10636 1/20 0.41
SMN1; SMN2 Q16637 1/20 0.39
PTGS1 P23219 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2376239 0.79 ENPP2 (0.72) ENPP2PTGS2
SCHEMBL7056902 0.78 ENPP2 (0.52) ENPP2PTGS2MAPTSMN1; SMN2
SCHEMBL5316865 0.78 ENPP2 (0.52) ENPP2PTGS2MAPTSMN1; SMN2
SCHEMBL5664827 0.76 POLB (0.57) SMN1; SMN2
SCHEMBL8328143 0.76 ENPP2 (0.50) ENPP2PTGS2MAPTSMN1; SMN2
SCHEMBL8724036 0.76 F2 (0.42) PTGS2PTGS1
SCHEMBL3044709 0.73 CYP3A4 (0.48) ENPP2PTGS2MAPTSMN1; SMN2
SCHEMBL9151778 0.73 MAPT (0.43) ENPP2PTGS2MAPTSMN1; SMN2PTGS1
SCHEMBL1304191 0.72 POLB (0.32) MAPTSMN1; SMN2
SCHEMBL13598185 0.71 CA1 (0.66) ENPP2PTGS2MAPTSMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4011208-A 3-CYANO OR ACYL-4-ARYL-5-ARYLAZO-6-HYDROXYPYRIDONE-2 DYES SANDOZ LTD. (CH) 1977-03-08 US claimed
US-5916721-A BINDER RESIN, AZOMETHINE DYE KONICA CORPORATION (JP) 1999-06-29 US disclosed
US-4011208-A 3-CYANO OR ACYL-4-ARYL-5-ARYLAZO-6-HYDROXYPYRIDONE-2 DYES SANDOZ LTD. (CH) 1977-03-08 US disclosed