Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHODH | Q02127 | 4/20 | 0.37 |
| ▸ | FFAR4 | Q5NUL3 | 4/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | NAPRT | Q6XQN6 | 1/20 | 0.33 |
| ▸ | IDO1 | P14902 | 1/20 | 0.32 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.32 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.32 |
| ▸ | ABL1 | P00519 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | GSK3B | P49841 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7964887 | 0.92 | L3MBTL1 (0.33) | DHODHFFAR4SCN9APDE4AHCRTR1 | |
| SCHEMBL7962621 | 0.91 | ABL1 (0.35) | SCN9APDE4AIDO1HCRTR1HCRTR2 | |
| SCHEMBL7963165 | 0.91 | SCN9A (0.34) | SCN9APDE4AHCRTR1HCRTR2ABL1 | |
| SCHEMBL8330824 | 0.89 | DHODH (0.43) | DHODHFFAR4NAPRTHCRTR1HCRTR2 | |
| SCHEMBL8328923 | 0.88 | DHODH (0.37) | DHODHIDO1HCRTR1HCRTR2KMT2A | |
| SCHEMBL8330821 | 0.85 | DHODH (0.36) | DHODHFFAR4NAPRTABL1 | |
| SCHEMBL8327360 | 0.83 | DHODH (0.35) | DHODHFFAR4NAPRTHCRTR1ABL1 | |
| SCHEMBL7965300 | 0.82 | KCNMA1 (0.34) | PDE4AHCRTR1HCRTR2ABL1 | |
| SCHEMBL8327934 | 0.82 | DHODH (0.35) | DHODHFFAR4NAPRTABL1KMT2A | |
| SCHEMBL7967665 | 0.82 | ABL1 (0.35) | DHODHIDO1HCRTR1HCRTR2ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0946555-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Aventis Pharma S.A. (FR) | 1999-10-06 | — | — | EP | claimed |
| WO-1998025925-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1998-06-18 | — | — | WO | claimed |
| EP-0946555-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Aventis Pharma S.A. (FR) | 1999-10-06 | — | — | EP | disclosed |
| WO-1998025925-A1 | PYRROLE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1998-06-18 | — | — | WO | disclosed |