Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2A | P28223 | 5/20 | 0.44 |
| ▸ | HTR2C | P28335 | 5/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 12/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8323145 | 0.82 | HTR2A (0.41) | HTR2AHTR2CNOTUMSIGMAR1HTR1A | |
| SCHEMBL8323142 | 0.82 | HTR2A (0.41) | HTR2AHTR2CNOTUMSIGMAR1HTR1A | |
| SCHEMBL8325900 | 0.81 | HTR2A (0.46) | HTR2AHTR2CNOTUMSIGMAR1HTR1A | |
| SCHEMBL8325766 | 0.80 | CRBN (0.46) | HTR2AHTR2CNOTUM | |
| SCHEMBL18911620 | 0.71 | HTR2A (0.60) | HTR2AHTR2CNOTUMSIGMAR1HTR1A | |
| SCHEMBL7300514 | 0.71 | HTR2A (0.60) | HTR2AHTR2CNOTUMSIGMAR1HTR1A | |
| SCHEMBL761931 | 0.70 | HTR2A (0.64) | HTR2AHTR2CNOTUMSIGMAR1HTR1A | |
| SCHEMBL30703022 | 0.70 | HTR2A (0.64) | HTR2AHTR2CNOTUMSIGMAR1HTR1A | |
| SCHEMBL18911621 | 0.69 | HTR2A (0.73) | HTR2AHTR2CNOTUMSIGMAR1HTR1A | |
| SCHEMBL8320735 | 0.69 | SIGMAR1 (0.39) | HTR2AHTR2CSIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |