Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 13/20 | 0.39 |
| ▸ | HTR2A | P28223 | 3/20 | 0.34 |
| ▸ | HTR2C | P28335 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.33 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.33 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327015 | 0.72 | CYP11B2 (0.53) | SIGMAR1USP30 | |
| SCHEMBL8326656 | 0.69 | CYP11B2 (0.48) | SIGMAR1USP30 | |
| SCHEMBL8325900 | 0.69 | HTR2A (0.46) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL8328249 | 0.69 | HTR2A (0.44) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL6590757 | 0.68 | KCNA3 (0.50) | SIGMAR1 | |
| SCHEMBL8325258 | 0.67 | CYP11B2 (0.53) | SIGMAR1USP30 | |
| SCHEMBL615033 | 0.66 | SIGMAR1 (0.63) | SIGMAR1 | |
| SCHEMBL8325766 | 0.66 | CRBN (0.46) | HTR2AHTR2C | |
| SCHEMBL6715677 | 0.66 | HTR2A (0.53) | SIGMAR1HTR2AHTR2C | |
| SCHEMBL3542987 | 0.66 | NOTUM (0.40) | SIGMAR1BRD4CREBBP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0470490-B1 | Substituted pyrroles | HOFFMANN LA ROCHE (CH) | 1999-05-06 | — | — | EP | disclosed |
| US-5292747-A | Substituted pyrroles | HOFFMAN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0470490-A1 | Substituted pyrroles | F. HOFFMANN-LA ROCHE AG (CH) | 1992-02-12 | — | — | EP | disclosed |