Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ATM | Q13315 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.35 |
| ▸ | ELANE | P08246 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.34 |
| ▸ | BRD4 | O60885 | 1/20 | 0.34 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.33 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.33 |
| ▸ | RAD52 | P43351 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.32 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.32 |
| ▸ | CDK4 | P11802 | 1/20 | 0.32 |
| ▸ | CCND1 | P24385 | 1/20 | 0.32 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.32 |
| ▸ | CDK2 | P24941 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326599 | 0.84 | KDM4E (0.38) | HPGDELANELMNABRD4ABCB1 | |
| SCHEMBL8327546 | 0.78 | HTT (0.41) | HPGDELANELMNABRD4SMN1; SMN2 | |
| SCHEMBL13415965 | 0.74 | BRD4 (0.44) | MAPTHPGDELANELMNABRD4 | |
| SCHEMBL11280877 | 0.72 | CSNK2A1 (0.44) | ATMHPGDLMNABRD4SMN1; SMN2 | |
| SCHEMBL7962458 | 0.71 | LMNA (0.36) | MAPTHPGDELANELMNABRD4 | |
| SCHEMBL11275611 | 0.70 | BRD4 (0.57) | HPGDLMNABRD4SMN1; SMN2CSNK2A1 | |
| SCHEMBL11270598 | 0.70 | PLK1 (0.41) | ATMHPGDLMNABRD4SMN1; SMN2 | |
| SCHEMBL1254852 | 0.69 | HPGD (0.39) | HPGDLMNABRD4SMN1; SMN2PLK1 | |
| SCHEMBL22917189 | 0.68 | BRD4 (0.42) | MAPTHPGDBRD4SMN1; SMN2PLK1 | |
| SCHEMBL22916957 | 0.68 | TP53 (0.50) | MAPTHPGDLMNABRD4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6002018-A | N-substituted 4-hydroxyindoline derivatives | L'OREAL (FR) | 1999-12-14 | — | — | US | disclosed |
| US-5869692-A | COUPLER FOR OXIDATION COLOR DYEING OF HAIR | L'OREAL (FR) | 1999-02-09 | — | — | US | disclosed |
| US-5755829-A | HAIR DYES USING HYDROXYINDOLE COUPLERS AND OXIDATION BASES | L'OREAL (FR) | 1998-05-26 | — | — | US | disclosed |
| EP-0754681-B1 | N-substituted 4-hydroxyindole derivatives and compositions for dyeing keratinous fibers containing them | OREAL (FR) | 1998-03-04 | — | — | EP | disclosed |
| US-5704948-A | Compositions for dyeing keratinous fibers and keratinous fiber dyeing processes with derivatives of 4-hydroxyindole and oxidation bases | L'OREAL (FR) | 1998-01-06 | — | — | US | disclosed |
| EP-0780118-B1 | Compositions for dyeing keratinous fibers containing N-substituted 4-hydroxy indoline derivatives, and certain of these derivatives | OREAL (FR) | 1997-12-29 | — | — | EP | disclosed |
| EP-0780118-A1 | Compositions for dyeing keratinous fibers containing N-substituted 4-hydroxy indoline derivatives, and certain of these derivatives | L'OREAL (FR) | 1997-06-25 | — | — | EP | disclosed |
| WO-1997003049-A1 | N-SUBSTITUTED 4-HYDROXYINDOLE DERIVATIVES AND KERATIN FIBRE DYEING COMPOSITIONS CONTAINING SAME | L'OREAL (FR) | 1997-01-30 | — | — | WO | disclosed |
| EP-0754681-A1 | N-substituted 4-hydroxy-indole derivatives and compositions for dyeing keratinous fibers containing them | L'OREAL (FR) | 1997-01-22 | — | — | EP | disclosed |