Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR84 | Q9NQS5 | 1/20 | 0.59 |
| ▸ | AXL | P30530 | 1/20 | 0.56 |
| ▸ | MET | P08581 | 2/20 | 0.51 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.50 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.49 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.46 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.46 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.45 |
| ▸ | CDK1 | P06493 | 1/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.45 |
| ▸ | CCNB3 | Q8WWL7 | 1/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.44 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.44 |
| ▸ | BRD4 | O60885 | 1/20 | 0.44 |
| ▸ | CDC7 | O00311 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29372615 | 0.96 | AXL (0.60) | GPR84AXLMETLRRK2KMT2A | |
| SCHEMBL12188 | 0.96 | AXL (0.60) | GPR84AXLMETLRRK2KMT2A | |
| SCHEMBL10044576 | 0.81 | AXL (0.53) | GPR84AXLMETLRRK2KMT2A | |
| SCHEMBL9383754 | 0.81 | AXL (0.45) | GPR84AXLMETLRRK2KMT2A | |
| SCHEMBL30491355 | 0.77 | AXL (0.39) | GPR84AXLMETLRRK2KMT2A | |
| SCHEMBL10081123 | 0.77 | GPR84 (0.59) | GPR84AXLMETLRRK2KMT2A | |
| Hydrochloric Acid SCHEMBL29243736 | 0.76 | GPR84 (0.58) | GPR84AXLMETLRRK2KMT2A | |
| SCHEMBL5618155 | 0.75 | TGFBR1 (0.71) | GPR84AXLLRRK2KMT2AMAP2K1 | |
| SCHEMBL858410 | 0.75 | TGFBR1 (0.57) | AXLMETLRRK2DYRK1APDPK1 | |
| SCHEMBL415187 | 0.75 | GPR84 (0.71) | GPR84AXLMETLRRK2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5976497-A | 3-(4-(2-PYRIDINYL))PIPERAZINYLMETHYL)PYRROLO(2.3-B)PYRIDINE AND DERIVATIVES | RESOLUTION PHARMACEUTICALS, INC. (CA) | 1999-11-02 | — | — | US | disclosed |
| WO-1999000386-A1 | DOPAMINE D4 RECEPTOR LIGANDS | RESOLUTION PHARMACEUTICALS INC. (CA) | 1999-01-07 | — | — | WO | disclosed |