Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 18/20 | 0.67 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.67 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.57 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8326982 | 0.93 | ROCK2 (0.58) | ROCK2CYP3A4ROCK1METAXL | |
| SCHEMBL2880069 | 0.80 | ROCK2 (1.00) | ROCK2CYP3A4ROCK1MET | |
| SCHEMBL8324210 | 0.78 | ROCK2 (1.00) | ROCK2CYP3A4ROCK1METAXL | |
| SCHEMBL2884105 | 0.76 | MET (0.44) | ROCK2CYP3A4ROCK1METAXL | |
| SCHEMBL10036320 | 0.75 | ROCK2 (1.00) | ROCK2CYP3A4ROCK1MET | |
| SCHEMBL2880092 | 0.74 | ROCK2 (0.73) | ROCK2CYP3A4ROCK1 | |
| SCHEMBL2879731 | 0.74 | ROCK2 (1.00) | ROCK2CYP3A4ROCK1 | |
| SCHEMBL2882221 | 0.73 | ROCK2 (0.86) | ROCK2CYP3A4MET | |
| SCHEMBL2879534 | 0.73 | MET (0.48) | ROCK2CYP3A4METAXL | |
| SCHEMBL8320434 | 0.73 | ROCK1 (0.87) | ROCK2CYP3A4ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7737153-B2 | Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-15 | — | — | US | disclosed |
| US-7737153-B2 | Heteroaryloxy-substituted phenylaminopyrimidines as rho-kinase inhibitors | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-06-15 | — | — | US | disclosed |
| WO-2004039796-A1 | HETEROARYLOXY-SUBSTITUTED PHENYLAMINOPYRIMIDINES AS RHO-KINASE INHIBITORS | BAYER HEALTHCARE AG (DE) | 2004-05-13 | — | — | WO | disclosed |