Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RARB | P10826 | 12/20 | 0.37 |
| ▸ | RARG | P13631 | 12/20 | 0.37 |
| ▸ | RARA | P10276 | 11/20 | 0.37 |
| ▸ | CDK5 | Q00535 | 5/20 | 0.35 |
| ▸ | CDK5R1 | Q15078 | 5/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | CASP3 | P42574 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.33 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.33 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.33 |
| ▸ | CLK1 | P49759 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8327478 | 0.87 | RARB (0.40) | RARBRARGRARARAB9ANPC1 | |
| SCHEMBL8331408 | 0.85 | RARB (0.37) | RARBRARGRARARAB9AGAA | |
| SCHEMBL8329764 | 0.84 | RARB (0.49) | RARBRARGRARARAB9AGAA | |
| SCHEMBL6237080 | 0.78 | RARA (0.53) | RARBRARGRARA | |
| SCHEMBL27554953 | 0.74 | RARB (0.39) | RARBRARGRARARAB9A | |
| SCHEMBL9007121 | 0.73 | RARA (0.43) | RARBRARGRARARAB9AGAA | |
| SCHEMBL9007048 | 0.70 | RARA (0.37) | RARBRARGRARARAB9AGAA | |
| SCHEMBL6240546 | 0.69 | RARA (0.66) | RARBRARGRARA | |
| SCHEMBL9006978 | 0.68 | NPC1 (0.34) | RARBRARGRARARAB9AGAA | |
| SCHEMBL8671303 | 0.68 | NPC1 (0.39) | RARBRARGRARARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5952345-A | RETINOID ACID RECEPTOR ANTAGONIST; A DERIVATIVES OF ARYL-SUBSTITUTED AND ARYL (3-OXO-1-PROPENLY)-SUBSTITUTED BENZOPYRAN, BENZOTHIOPYRAN, 1,2-DIHYDROQUINOLINE; PREVENTING TOXICITY OR SIDE EFFECTS CAUSED BY RETINOIDS OR VITAMIN A | ALLERGAN SALES, INC. (US) | 1999-09-14 | — | — | US | disclosed |
| US-5877207-A | SKIN DISORDERS; ANTICARCINOGENIC AGENTS | ALLERGAN SALES, INC. (US) | 1999-03-02 | — | — | US | disclosed |
| US-5776699-A | MEASURING GENE EXPRESSION | ALLERGAN, INC. (US) | 1998-07-07 | — | — | US | disclosed |