SCHEMBL8329259

SCHEMBL8329259

CC(=O)Nc1sc2ccccc2c1C(=O)O

nearest known ligand 0.63

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ABCC1 P33527 2/20 0.63
ABCG2 Q9UNQ0 1/20 0.63
ACLY P53396 1/20 0.54
PKM P14618 1/20 0.47
PARP14 Q460N5 1/20 0.47
PRNP P04156 1/20 0.47
RXFP1 Q9HBX9 1/20 0.47
LMNA P02545 2/20 0.46
MAPK1 P28482 1/20 0.46
MAPT P10636 3/20 0.43
ALDH1A1 P00352 2/20 0.43
GAA P10253 2/20 0.43
KDM4E B2RXH2 2/20 0.43
POLB P06746 1/20 0.43
CYP1A2 P05177 1/20 0.43
CYP3A4 P08684 1/20 0.43
CYP2D6 P10635 1/20 0.43
CYP2C9 P11712 1/20 0.43
HK1 P19367 1/20 0.43
CYP2C19 P33261 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4059329 0.88 ABCC1 (0.50) ABCC1ABCG2ACLYPKMPARP14
SCHEMBL6654580 0.84 LMNA (0.63) ABCC1ABCG2PKMPARP14RXFP1
SCHEMBL2210016 0.81 ABCC1 (0.63) ABCC1ABCG2ACLY
SCHEMBL3498296 0.80 ABCC1 (0.77) ABCC1ABCG2ACLYPRNPRXFP1
SCHEMBL21250173 0.80 MEN1 (0.60) ABCC1ABCG2ACLYPRNPRXFP1
SCHEMBL5165684 0.80 MAPT (0.67) ABCC1ABCG2RXFP1LMNAMAPK1
SCHEMBL3497629 0.80 ABCC1 (0.55) ABCC1ABCG2ACLYPRNPRXFP1
SCHEMBL5741331 0.79 ABCC1 (0.57) ABCC1ABCG2ACLYLMNAMAPT
SCHEMBL11189958 0.78 PKM (0.43) ABCC1ABCG2PKMPARP14RXFP1
SCHEMBL13980047 0.77 MAPT (0.68) ABCC1ABCG2PARP14LMNAMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0912180-A1 HETEROCYCLIC COMPOUNDS WITH THROMBOLYTIC ACTIVITY AND THEIR USE FOR TREATING THROMBOSIS Dupin, Jean-Pierre (FR) 1999-05-06 EP disclosed
WO-1998002162-A1 HETEROCYCLIC COMPOUNDS WITH THROMBOLYTIC ACTIVITY AND THEIR USE FOR TREATING THROMBOSIS DUPIN JEAN PIERRE (FR) 1998-01-22 WO disclosed
US-4396621-A ANALGESICS, ANTIIMFLAMMATORY AGENTS CIBA-GEIGY CORPORATION (US) 1983-08-02 US disclosed