Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.63 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.63 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.53 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | ATM | Q13315 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | HK1 | P19367 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.51 |
| ▸ | MEN1 | O00255 | 2/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5165684 | 0.86 | MAPT (0.67) | LMNAMAPK1KDM4EMAPTCYP1A2 | |
| SCHEMBL8329259 | 0.84 | ABCC1 (0.63) | LMNAMAPK1KDM4EMAPTGAA | |
| SCHEMBL4059329 | 0.82 | ABCC1 (0.50) | LMNAMAPK1L3MBTL1TDP1MAPT | |
| SCHEMBL7845889 | 0.82 | LMNA (0.52) | LMNAMAPK1L3MBTL1TDP1ATM | |
| SCHEMBL3599532 | 0.81 | LMNA (0.71) | LMNAMAPK1L3MBTL1TDP1ATM | |
| SCHEMBL7847580 | 0.80 | LMNA (0.50) | LMNAMAPK1L3MBTL1TDP1ATM | |
| SCHEMBL15699989 | 0.78 | LMNA (0.58) | LMNAMAPK1L3MBTL1TDP1ATM | |
| SCHEMBL14304674 | 0.78 | ALDH1A1 (0.45) | LMNAMAPK1KDM4EMAPTGAA | |
| SCHEMBL9495325 | 0.78 | LMNA (1.00) | LMNAMAPK1L3MBTL1TDP1ATM | |
| SCHEMBL6656348 | 0.76 | LMNA (0.69) | LMNAMAPK1L3MBTL1TDP1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | VANDERBILT UNIVERSITY | 2017-07-06 | — | — | US | disclosed |
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | VANDERBILT UNIVERSITY | 2017-07-06 | — | — | US | disclosed |
| US-20160240791-A1 | COMPOUND FOR ORGANIC OPTOELECTRONIC DEVICE AND ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE | SAMSUNG SDI CO., LTD. (KR) | 2016-08-18 | — | — | US | disclosed |
| US-20160240791-A1 | COMPOUND FOR ORGANIC OPTOELECTRONIC DEVICE AND ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE | SAMSUNG SDI CO., LTD. (KR) | 2016-08-18 | — | — | US | disclosed |
| EP-1280792-B1 | METHOD FOR PRODUCING BENZO ANNELATED HETEROCYCLES | MERCK PATENT GMBH (DE) | 2004-07-14 | — | — | EP | disclosed |
| US-6723848-B2 | TETRAHYDROBENZOFURAN OR TETRAHYDROBENZOTHIOPHEN OR TETRAHDYROBENZOPYRROLE COMPOUNDS CAN BE AROMATIZED WITH A HYDROGENATION CATALYST IN PRESENCE OF A HYDROGEN ACCEPTOR, DEACYLATION OF AMINO GROUP BY ADDITION OF AN AMINE GROUP | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 2004-04-20 | — | — | US | disclosed |
| US-20030078422-A1 | Method for producing benzo annelated heterocycles | MERCK PATENT GMBH (DE) | 2003-04-24 | — | — | US | disclosed |
| EP-1280792-A1 | METHOD FOR PRODUCING BENZO ANNELATED HETEROCYCLES | MERCK PATENT GmbH (DE) | 2003-02-05 | — | — | EP | disclosed |
| WO-2001077099-A1 | METHOD FOR PRODUCING BENZO ANNELATED HETEROCYCLES | MERCK PATENT GMBH (DE) | 2001-10-18 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170190717-A1 | Compounds and Methods for Inhibition of Hedgehog Signaling and Phosphodiesterase | PDE4A, PDE4B, PDE7A | LMNA 3846/4885MAPK1 916/4885L3MBTL1 3099/4885 |
| US-20160240791-A1 | COMPOUND FOR ORGANIC OPTOELECTRONIC DEVICE AND ORGANIC OPTOELECTRONIC DEVICE AND DISPLAY DEVICE | OR10J3, OXER1, OCIAD1 | LMNA 4847/4885MAPK1 473/4885L3MBTL1 4625/4885 |
| US-20030078422-A1 | Method for producing benzo annelated heterocycles | NAT1, AFF1, SAT1 | LMNA 3472/4885MAPK1 1004/4885L3MBTL1 3073/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.