Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.32 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.32 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | GBA1 | P04062 | 1/20 | 0.31 |
| ▸ | ALOX5AP | P20292 | 4/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.30 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8330832 | 0.87 | ADORA2A (0.38) | ADORA2AADORA1CYP2A6KCNJ5KCNJ3 | |
| SCHEMBL18649540 | 0.75 | CYP2A6 (0.38) | ADORA2AADORA1CYP2A6KCNJ5KCNJ3 | |
| SCHEMBL3624702 | 0.65 | ADORA2A (0.44) | ADORA2AADORA1CYP2A6KCNJ5KCNJ3 | |
| SCHEMBL15955785 | 0.65 | HSD17B10 (0.40) | ADORA2AADORA1CYP2A6KDM4EALOX5AP | |
| SCHEMBL8325387 | 0.62 | ADORA2A (0.37) | ADORA2AADORA1CYP2A6KCNJ5KCNJ3 | |
| SCHEMBL2628881 | 0.62 | AXL (0.36) | ADORA2AADORA1CYP2A6KCNJ5KCNJ3 | |
| SCHEMBL8671760 | 0.61 | TDP1 (0.45) | ADORA2AADORA1CYP2A6KCNJ5KCNJ3 | |
| SCHEMBL12301439 | 0.61 | KDM4E (0.41) | CYP2A6KDM4EPOLBLMNACYP1A2 | |
| SCHEMBL13140313 | 0.61 | ADORA2A (0.41) | ADORA2AADORA1CYP2A6KCNJ5KCNJ3 | |
| SCHEMBL14833461 | 0.61 | CYP2A6 (0.38) | ADORA2AADORA1CYP2A6KCNJ5KCNJ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544210-B1 | Process for the preparation of in position 5 substituted cytosines and of other 4,5-disubstituted pyrimidin-2(1H)-ones, also the forth-issuing intermediates | HOECHST AG (DE) | 1999-11-03 | — | — | EP | disclosed |
| US-5359067-A | Process for the preparation of 5-substituted cytosines and other 4,5-disubstituted pyrimidin-2(1H)-ones, and intermediates arising in the course of this | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-10-25 | — | — | US | disclosed |
| EP-0544210-A1 | Process for the preparation of in position 5 substituted cytosines and of other 4,5-disubstituted pyrimidin-2(1H)-ones, also the forth-issuing intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-06-02 | — | — | EP | disclosed |