Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.34 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GBA1 | P04062 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 5/20 | 0.33 |
| ▸ | PDE4A | P27815 | 3/20 | 0.32 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8329276 | 0.87 | ADORA2A (0.35) | ADORA2AADORA1CYP2A6KCNJ5KCNJ3 | |
| SCHEMBL18649540 | 0.77 | CYP2A6 (0.38) | ADORA2AADORA1CYP2A6KCNJ5KCNJ3 | |
| SCHEMBL15955785 | 0.76 | HSD17B10 (0.40) | ADORA2AADORA1CYP2A6KDM4ELMNA | |
| SCHEMBL3624702 | 0.70 | ADORA2A (0.44) | ADORA2AADORA1CYP2A6KCNJ5KCNJ3 | |
| SCHEMBL22325535 | 0.68 | CYP2A6 (0.40) | CYP2A6KDM4ECYP1A2CYP2D6CYP2C9 | |
| SCHEMBL2898324 | 0.68 | CYP2A6 (0.40) | CYP2A6KDM4EPDE10ACYP1A2CYP2D6 | |
| SCHEMBL28333293 | 0.68 | HTR3A (0.46) | CYP2A6KDM4EPDE10ACYP1A2LMNA | |
| SCHEMBL8325387 | 0.67 | ADORA2A (0.37) | ADORA2AADORA1CYP2A6KCNJ5KCNJ3 | |
| SCHEMBL13140313 | 0.66 | ADORA2A (0.41) | ADORA2AADORA1CYP2A6KCNJ5KCNJ3 | |
| SCHEMBL10759266 | 0.65 | CYP2A6 (0.48) | CYP2A6KDM4EPDE10ACYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544210-B1 | Process for the preparation of in position 5 substituted cytosines and of other 4,5-disubstituted pyrimidin-2(1H)-ones, also the forth-issuing intermediates | HOECHST AG (DE) | 1999-11-03 | — | — | EP | disclosed |
| US-5359067-A | Process for the preparation of 5-substituted cytosines and other 4,5-disubstituted pyrimidin-2(1H)-ones, and intermediates arising in the course of this | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-10-25 | — | — | US | disclosed |
| EP-0544210-A1 | Process for the preparation of in position 5 substituted cytosines and of other 4,5-disubstituted pyrimidin-2(1H)-ones, also the forth-issuing intermediates | HOECHST AKTIENGESELLSCHAFT (DE) | 1993-06-02 | — | — | EP | disclosed |