SCHEMBL5313810

SCHEMBL5313810

Cc1nc(-c2n[nH]c3cccc(Cc4ccccc4)c23)oc1CO

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAP2K4 P45985 4/20 0.37
MAPK1 P28482 3/20 0.35
CYP1A2 P05177 2/20 0.35
CYP3A4 P08684 2/20 0.35
CYP2D6 P10635 2/20 0.35
CYP2C9 P11712 2/20 0.35
CYP2C19 P33261 2/20 0.35
MAPKAPK2 P49137 1/20 0.35
MAPK6 Q16659 1/20 0.35
SLC5A1 P13866 1/20 0.33
SLC5A2 P31639 1/20 0.33
GAA P10253 1/20 0.31
ITK Q08881 1/20 0.31
FGFR3 P22607 1/20 0.31
NPC1 O15118 2/20 0.30
RAB9A P51151 2/20 0.30
SMN1; SMN2 Q16637 2/20 0.30
HPGD P15428 1/20 0.30
POLB P06746 1/20 0.30
NR1H2 P55055 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5312666 0.87 MAP4K1 (0.35) MAP2K4MAPK1MAPKAPK2MAPK6SLC5A1
SCHEMBL5314525 0.87 MAPK1 (0.34) MAP2K4MAPK1CYP1A2CYP3A4CYP2D6
SCHEMBL5313829 0.85 ALDH1A1 (0.36) MAP2K4MAPK1CYP1A2CYP3A4CYP2D6
SCHEMBL163795 0.75 HIF1A (0.44) MAP2K4MAPK1CYP1A2CYP3A4CYP2D6
SCHEMBL5314312 0.75 PPARD (0.34) MAP2K4MAPK1MAPKAPK2MAPK6NPSR1
SCHEMBL5419366 0.75 AR (0.32) MAP2K4MAPK1MAPKAPK2MAPK6SLC5A1
SCHEMBL8329288 0.75 PDE5A (0.40) MAP2K4MAPK1CYP1A2CYP3A4CYP2D6
SCHEMBL5312041 0.74 MAPK1 (0.37) MAP2K4MAPK1CYP1A2CYP3A4CYP2D6
SCHEMBL5314638 0.74 MAP2K4 (0.43) MAP2K4MAPK1CYP1A2CYP3A4CYP2D6
SCHEMBL5430240 0.73 SMN1; SMN2 (0.42) GAANPC1RAB9ASMN1; SMN2HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2007065010-A2 ANTI-ANGIOGENESIS COMPOUNDS HIF BIO, INC. (US) 2007-06-07 WO disclosed
EP-0934311-A2 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES BAYER AG (DE) 1999-08-11 EP disclosed
WO-1998016507-A2 NEW HETEROCYCLYLMETHYL-SUBSTITUTED PYRAZOL DERIVATES AND THEIR USE FOR TREATING CARDIOVASCULAR DISEASES BAYER AKTIENGESELLSCHAFT (DE) 1998-04-23 WO disclosed