Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 2/20 | 0.51 |
| ▸ | CTSB | P07858 | 2/20 | 0.51 |
| ▸ | PLAAT3 | P53816 | 4/20 | 0.50 |
| ▸ | PLAAT5 | Q96KN8 | 4/20 | 0.50 |
| ▸ | PLAAT2 | Q9NWW9 | 4/20 | 0.50 |
| ▸ | PLAAT4 | Q9UL19 | 4/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | CASP3 | P42574 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.47 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.47 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12040536 | 0.72 | TAAR1 (0.59) | PLAAT3PLAAT5PLAAT2PLAAT4MEN1 | |
| SCHEMBL28107403 | 0.72 | BCHE (0.56) | NPC1RAB9ATDP1MEN1KMT2A | |
| SCHEMBL155800 | 0.71 | TDP1 (0.55) | NPC1CASP3RAB9ASENP8SENP7 | |
| SCHEMBL657718 | 0.71 | PLAAT3 (0.57) | CTSLCTSBPLAAT3PLAAT5PLAAT2 | |
| SCHEMBL7375927 | 0.71 | TBXAS1 (0.55) | TDP1KMT2AL3MBTL1 | |
| SCHEMBL6983189 | 0.71 | GRIN2B (0.50) | CTSLCTSBPLAAT3PLAAT5PLAAT2 | |
| SCHEMBL5024832 | 0.70 | SMN1; SMN2 (0.68) | PLAAT3PLAAT5PLAAT2PLAAT4MEN1 | |
| SCHEMBL23071686 | 0.69 | TAAR1 (0.65) | PLAAT3PLAAT5PLAAT2PLAAT4MEN1 | |
| SCHEMBL10336435 | 0.69 | TDP1 (0.60) | PLAAT3PLAAT5PLAAT2PLAAT4NPC1 | |
| SCHEMBL27472305 | 0.68 | PLAAT3 (0.60) | PLAAT3PLAAT5PLAAT2PLAAT4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0948496-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDONE COMPOUNDS AND METHODS OF USE | Amgen inc. (US) | 1999-10-13 | — | — | EP | disclosed |
| WO-1998024780-A2 | SUBSTITUTED PYRIMIDINONE AND PYRIDINONE COMPOUNDS AND THEIR USE | AMGEN INC. (US) | 1998-06-11 | — | — | WO | disclosed |