Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 1/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.46 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.46 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.46 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.46 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.45 |
| ▸ | PTPRB | P23467 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8803281 | 0.90 | HDAC3 (0.51) | IDO1SYKHDAC3HDAC4HDAC1 | |
| SCHEMBL8799761 | 0.89 | CYP3A4 (0.44) | IDO1SYKMAPTPTPRBCYP3A4 | |
| SCHEMBL8799056 | 0.89 | SIGMAR1 (0.51) | IDO1SYKHDAC3HDAC4HDAC1 | |
| SCHEMBL8798754 | 0.88 | CYP3A4 (0.57) | IDO1SYKHDAC3HDAC4HDAC1 | |
| SCHEMBL8800029 | 0.85 | KEAP1 (0.42) | IDO1MAPTPTPRBL3MBTL1CYP3A4 | |
| SCHEMBL8633540 | 0.83 | IDO1 (0.46) | IDO1SYKHDAC3HDAC4HDAC1 | |
| SCHEMBL8798252 | 0.81 | CYP3A4 (0.56) | IDO1HDAC3HDAC4HDAC1HDAC7 | |
| SCHEMBL8633439 | 0.79 | NPSR1 (0.46) | IDO1SYKMAPTPTPRBCYP3A4 | |
| SCHEMBL8331034 | 0.79 | TDP1 (0.44) | IDO1HTTPTPRBALDH1A1MEN1 | |
| SCHEMBL8800128 | 0.79 | CA12 (0.47) | MAPTL3MBTL1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908863-A | ANTIGROWTH AGENT FOR BONES | DOMPE' S.P.A. (IT) | 1999-06-01 | — | — | US | disclosed |
| EP-0792878-A2 | Geminal carboxylic acids and esters thereof, pharmaceutical formulations containing them useful in the treatment of bone dysmetabolism | Dompé S.P.A. (IT) | 1997-09-03 | — | — | EP | disclosed |