Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FOLH1 | Q04609 | 3/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | GAA | P10253 | 1/20 | 0.46 |
| ▸ | MYC | P01106 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | HNF4A | P41235 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28522033 | 0.87 | FOLH1 (0.54) | FOLH1ALDH1A1ALOX15MYCL3MBTL1 | |
| SCHEMBL30565103 | 0.84 | FOLH1 (0.59) | FOLH1CYP2C9ALDH1A1ALOX15HTT | |
| SCHEMBL445508 | 0.84 | FOLH1 (0.59) | FOLH1CYP2C9ALDH1A1ALOX15HTT | |
| SCHEMBL9336233 | 0.82 | AKR1B1 (0.55) | CYP2C9KDM4EHPGD | |
| SCHEMBL7969105 | 0.82 | FOLH1 (0.56) | FOLH1CYP3A4CYP2C9ALOX12ALDH1A1 | |
| SCHEMBL7843765 | 0.82 | FOLH1 (0.56) | FOLH1CYP3A4CYP2C9ALOX12ALDH1A1 | |
| Hydrochloric Acid SCHEMBL3312470 | 0.82 | FOLH1 (0.57) | FOLH1CYP2C9ALDH1A1ALOX15HTT | |
| SCHEMBL36145 | 0.81 | ALDH1A1 (0.72) | FOLH1CYP3A4CYP2C9ALOX12ALDH1A1 | |
| SCHEMBL30028907 | 0.81 | ALDH1A1 (0.72) | FOLH1CYP3A4CYP2C9ALOX12ALDH1A1 | |
| SCHEMBL200710 | 0.81 | FOLH1 (0.54) | FOLH1CYP3A4CYP2C9ALOX12ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2016089845-A1 | A CONVERGENT APPROACH TO THE TOTAL SYNTHESIS OF TELMISARTAN VIA A SUZUKI CROSS-COUPLING REACTION | VIRGINIA COMMONWEALTH UNIVERSITY (US) | 2016-06-09 | — | — | WO | disclosed |
| WO-2013078237-A1 | N-ARYLYLMETHYLINDAZOLE MODULATORS OF PPARG | RIPKA AMY S (US) | 2013-05-30 | — | — | WO | disclosed |
| WO-2012170554-A1 | N-BIPHENYLMETHYLINDOLE MODULATORS OF PPARG | KAMENECKA THEODORE MARK (US) | 2012-12-13 | — | — | WO | disclosed |
| CN-1204124-C | New preparation method of timixatan | SHANGHAI INST MATERIA MEDICA (CN) | 2005-06-01 | — | — | CN | disclosed |
| CN-1182122-C | Synthesis path of Timisatem | 中国科学院上海药物研究所 | 2004-12-29 | — | — | CN | disclosed |
| CN-1412183-A | New preparation method of timixatan | SHANGHAI INST OF MEDICINE CHIN (CN) | 2003-04-23 | — | — | CN | disclosed |
| CN-1344712-A | Synthesis path of Timisatem | SHANGHAI INST OF PHARMACOLOGY (CN) | 2002-04-17 | — | — | CN | disclosed |
| EP-0498721-B1 | N-substituted quinoline derivatives, process for their preparation, their use as pharmaceuticals and pharmaceutical compositions containing them | HOECHST MARION ROUSSEL INC (FR) | 1999-12-22 | — | — | EP | disclosed |
| WO-1992016524-A1 | BENZO-FUSED LACTAMS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1992-10-01 | — | — | WO | disclosed |
| EP-0498721-A1 | N-substituted quinoline derivatives, process for their preparation, intermediates obtained, their use as pharmaceuticals and pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1992-08-12 | — | — | EP | disclosed |
| EP-0461040-A1 | Imidazol derivatives, their process for production, intermediates, their application as medicaments and the pharmaceutical compositions containing them | ROUSSEL UCLAF (FR) | 1991-12-11 | — | — | EP | disclosed |