Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX1 | P07099 | 1/20 | 0.49 |
| ▸ | PTPRB | P23467 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.40 |
| ▸ | CTSK | P43235 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA2 | P00918 | 2/20 | 0.35 |
| ▸ | CA9 | Q16790 | 2/20 | 0.35 |
| ▸ | METAP2 | P50579 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8328919 | 0.94 | EPHX1 (0.46) | EPHX1PTPRBKMT2AMEN1ALDH1A1 | |
| SCHEMBL8323679 | 0.89 | EPHX1 (0.44) | EPHX1PTPRBKMT2AMEN1ALDH1A1 | |
| SCHEMBL8327495 | 0.84 | EPHX1 (0.46) | EPHX1PTPRBKMT2AMEN1ALDH1A1 | |
| SCHEMBL8332090 | 0.82 | METAP2 (0.38) | EPHX1KMT2AMEN1TSHRCTSS | |
| SCHEMBL8331369 | 0.82 | MEN1 (0.36) | EPHX1KMT2AMEN1ALDH1A1TSHR | |
| SCHEMBL8331769 | 0.82 | EPHX1 (0.44) | EPHX1PTPRBKMT2AMEN1ALDH1A1 | |
| SCHEMBL8328587 | 0.81 | EPHX1 (0.33) | EPHX1PTPRBKMT2AMEN1TSHR | |
| SCHEMBL8329421 | 0.80 | METAP2 (0.40) | EPHX1KMT2AMEN1ALDH1A1GAA | |
| SCHEMBL8328926 | 0.78 | METAP2 (0.38) | KMT2AMEN1CTSSCTSKMETAP2 | |
| SCHEMBL8328594 | 0.78 | REN (0.39) | CTSSCTSKMETAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908863-A | ANTIGROWTH AGENT FOR BONES | DOMPE' S.P.A. (IT) | 1999-06-01 | — | — | US | disclosed |
| EP-0792878-A2 | Geminal carboxylic acids and esters thereof, pharmaceutical formulations containing them useful in the treatment of bone dysmetabolism | Dompé S.P.A. (IT) | 1997-09-03 | — | — | EP | disclosed |