⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1673128 | 0.68 | — | — | |
| SCHEMBL967911 | 0.65 | — | — | |
| SCHEMBL3987076 | 0.65 | KDM4E (0.33) | — | |
| SCHEMBL5035031 | 0.64 | LMNA (0.40) | — | |
| SCHEMBL389955 | 0.63 | — | — | |
| SCHEMBL1838763 | 0.63 | — | — | |
| SCHEMBL16766999 | 0.62 | LMNA (0.36) | — | |
| SCHEMBL114603 | 0.61 | — | — | |
| SCHEMBL2065823 | 0.61 | — | — | |
| SCHEMBL2425762 | 0.60 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5877182-A | Piperidines promote release of growth hormone | MERCK & CO., INC. (US) | 1999-03-02 | — | — | US | claimed |
| US-5804578-A | USEFUL FOR TREATING OSTEOPROSIS, CATABOLIC ILLNESS, IMMUNE DEFICIENCY, BONE FRACTURE, SHROT STATURE IN CHILDREN, OBASITY, SLEEP DISORDER, CACHEXIA AND PROTEIN LOSS DUE TO CHRONIC ILLNESS SUCH AS AIDS AND CANCER | MERCK & CO., INC. (US) | 1998-09-08 | — | — | US | claimed |
| WO-1998025897-A1 | PIPERIDINES, PYRROLIDINES AND HEXAHYDRO-1H-AZEPINES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1998-06-18 | — | — | WO | claimed |
| WO-1998010653-A1 | PIPERIDINES, PYRROLIDINES AND HEXAHYDRO-1H-AZEPINES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1998-03-19 | — | — | WO | claimed |
| WO-1997036873-A1 | PIPERIDINES, PYRROLIDINES AND HEXAHYDRO-1H-AZEPINES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | claimed |
| CN-109942567-A | A kind of 1,3,4- dislikes the glyoxaline compound and its preparation method and application of (thiophene) di azoly | 贵州大学 | 2019-06-28 | — | — | CN | disclosed |
| CN-107056773-A | Pyrazoles Lian Evil containing pyridiniujm（Thiophene）Diazoles compound and preparation method and application | 贵州大学 | 2017-08-18 | — | — | CN | disclosed |
| US-5965565-A | PIPERIDINES, PYRROLIDINES, AND HEXAHYDRO-1H-AZEPINES OF GIVEN FORMULA; CAN BE USED TO PROMOTE GROWTH OF LIVESTOCK AND IN HUMANS TREAT PHYSIOLOGICAL OR MEDICAL CONDITIONS CHARACTERIZED BY GRWOTH HORMONE DEFIENCY | MERCK & CO., INC. (US) | 1999-10-12 | — | — | US | disclosed |
| US-5877182-A | Piperidines promote release of growth hormone | MERCK & CO., INC. (US) | 1999-03-02 | — | — | US | disclosed |
| US-5804578-A | USEFUL FOR TREATING OSTEOPROSIS, CATABOLIC ILLNESS, IMMUNE DEFICIENCY, BONE FRACTURE, SHROT STATURE IN CHILDREN, OBASITY, SLEEP DISORDER, CACHEXIA AND PROTEIN LOSS DUE TO CHRONIC ILLNESS SUCH AS AIDS AND CANCER | MERCK & CO., INC. (US) | 1998-09-08 | — | — | US | disclosed |
| WO-1998025897-A1 | PIPERIDINES, PYRROLIDINES AND HEXAHYDRO-1H-AZEPINES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1998-06-18 | — | — | WO | disclosed |
| WO-1998010653-A1 | PIPERIDINES, PYRROLIDINES AND HEXAHYDRO-1H-AZEPINES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1998-03-19 | — | — | WO | disclosed |
| WO-1997036873-A1 | PIPERIDINES, PYRROLIDINES AND HEXAHYDRO-1H-AZEPINES PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1997-10-09 | — | — | WO | disclosed |