SCHEMBL8330132

SCHEMBL8330132

CC(C)(N(CP(=O)(O)O)C(C)(C)P(=O)(O)O)P(=O)(O)O

nearest known ligand 0.38

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
LMNA P02545 1/20 0.38
FDPS P14324 5/20 0.36
GRM4 Q14833 1/20 0.34
KDM4E B2RXH2 1/20 0.30
MMP2 P08253 1/20 0.30
THRB P10828 1/20 0.30
MAPK1 P28482 1/20 0.30
HSD17B10 Q99714 1/20 0.30
USP2 O75604 1/20 0.30
ALOX15 P16050 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10976994 0.80 LMNA (0.38) LMNAFDPSGRM4KDM4EMMP2
SCHEMBL13645503 0.77 LMNA (0.39) LMNAFDPSMMP2
SCHEMBL3981963 0.69 LMNA (0.47) LMNAFDPSGRM4
SCHEMBL9715325 0.67 GRM4 (0.36) LMNAFDPSGRM4KDM4EMMP2
SCHEMBL11572056 0.67 FDPS (0.38) LMNAFDPSGRM4KDM4EMMP2
SCHEMBL3380723 0.65 LMNA (0.43) LMNAFDPS
SCHEMBL1191901 0.65 LMNA (0.43) LMNAFDPS
SCHEMBL27006289 0.65 LMNA (0.56) LMNAFDPSGRM4KDM4EMMP2
SCHEMBL4353438 0.64
SCHEMBL384746 0.64 USP2 (0.42) FDPSKDM4EMMP2THRBMAPK1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0802919-A4 RAPIDLY CLEARING TECHNETIUM-99m PHOSPHONATE SKELETAL IMAGING AGENTS MALLINCKRODT MEDICAL INC (US) 1999-08-18 EP disclosed
EP-0802919-A1 RAPIDLY CLEARING TECHNETIUM-99m PHOSPHONATE SKELETAL IMAGING AGENTS MALLINCKRODT MEDICAL, INC. (US) 1997-10-29 EP disclosed
WO-1995033757-A1 RAPIDLY CLEARING TECHNETIUM-99m PHOSPHONATE SKELETAL IMAGING AGENTS MALLINCKRODT MEDICAL, INC. (US) 1995-12-14 WO disclosed
US-4497744-A Gentisic acid salts as radiographic scanning agent stabilizers MALLINCKRODT, INC. (US) 1985-02-05 US disclosed
EP-0006658-B1 RADIOACTIVE SCANNING AGENTS WITH HYDROQUINONE AS STABILIZER AND METHOD FOR PREPARING THEM THE PROCTER & GAMBLE COMPANY (US) 1982-08-11 EP disclosed
US-4330537-A PHOSPHONATE COMPOUNDS AND VITAMIN D DERIVATIVES USEFUL AGAINST OSTEOPORSIS THE PROCTER & GAMBLE COMPANY (US) 1982-05-18 US disclosed
EP-0006659-B1 COMPOSITIONS USEFUL IN THE PREPARATION OF STABILIZED RADIOGRAPHIC SCANNING AGENTS, A METHOD OF PREPARING THEM AND THE USE OF STANNOUS GENTISILATE AS STABILIZER IN THESE COMPOSITIONS THE PROCTER & GAMBLE COMPANY (US) 1982-04-21 EP disclosed
EP-0004684-B1 STABILIZED RADIOGRAPHIC SCANNING AGENTS AND METHOD FOR PREPARING THEM THE PROCTER & GAMBLE COMPANY (US) 1981-09-16 EP disclosed
US-4233284-A GENESTIC ACID, SALT OR ESTER THEREOF IN COMBINATION WITH A PERTECHNETATE REDUCING AGENT BECOMES LOCALIZED IN SPECIFIC BODY ORGANS OR BONES THE PROCTER & GAMBLE COMPANY (US) 1980-11-11 US disclosed
US-4232000-A GENTISYL ALCOHOL, REDUCING AGENT THE PROCTER & GAMBLE COMPANY (US) 1980-11-04 US disclosed
US-4230700-A ADMINISTERING AN ORGANIC MONO- OR DIPHOSPHONATE AND A VITAMIN-D-LIKE ANTIRACHITIC COMPOUND THE PROCTER & GAMBLE COMPANY (US) 1980-10-28 US disclosed
US-4229427-A REDUCING AGENTS FOR PERTECHNETATE; MEDICAL DIAGNOSIS THE PROCTER & GAMBLE COMPANY (US) 1980-10-21 US disclosed
EP-0006659-A1 Compositions useful in the preparation of stabilized radiographic scanning agents, a method of preparing them and the use of stannous gentisilate as stabilizer in these compositions THE PROCTER & GAMBLE COMPANY (US) 1980-01-09 EP disclosed
EP-0006658-A1 Radioactive scanning agents with hydroquinone as stabilizer and method for preparing them THE PROCTER & GAMBLE COMPANY (US) 1980-01-09 EP disclosed
EP-0004684-A2 Stabilized radiographic scanning agents and method for preparing them THE PROCTER & GAMBLE COMPANY (US) 1979-10-17 EP disclosed
US-4051234-A BIS-GUANIDINE COMPOUND, ETHYLENEDIAMINEDIACETIC ACID OR SALT AS CHELATOR THE PROCTER & GAMBLE COMPANY (US) 1977-09-27 US disclosed
US-4025616-A Oral compositions for plaque, caries and calculus retardation with reduced staining tendencies THE PROCTER & GAMBLE COMPANY (US) 1977-05-24 US disclosed
US-3983227-A TECHNETIUM THE PROCTER & GAMBLE COMPANY (US) 1976-09-28 US disclosed
US-3965254-A Compositions for the treatment of calcific tumors THE PROCTER & GAMBLE COMPANY (US) 1976-06-22 US disclosed
US-3934002-A BIS-GUANIDE THE PROCTER & GAMBLE COMPANY (US) 1976-01-20 US disclosed