Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 2/20 | 0.49 |
| ▸ | HTR2A | P28223 | 5/20 | 0.43 |
| ▸ | HTR2C | P28335 | 5/20 | 0.43 |
| ▸ | HTR2B | P41595 | 5/20 | 0.43 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8331075 | 0.85 | KDM1A (0.45) | KDM1AHTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL8331070 | 0.84 | HTR2C (0.44) | KDM1AHTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL8332820 | 0.82 | KDM1A (0.43) | KDM1AHTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL8333596 | 0.82 | SLC9A1 (0.47) | HTR2AHTR2CHTR2BSLC6A3HRH3 | |
| SCHEMBL7002740 | 0.81 | MAOA (0.51) | KDM1AHTR2CSLC6A3MAPTHDAC4 | |
| SCHEMBL8332789 | 0.80 | SLC9A1 (0.51) | HTR2AHTR2CHTR2B | |
| SCHEMBL25606213 | 0.75 | KDM1A (0.54) | KDM1AHTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL6753587 | 0.75 | HTR2A (0.42) | KDM1AHTR2AHTR2CHTR2B | |
| SCHEMBL6753585 | 0.75 | HTR2A (0.42) | KDM1AHTR2AHTR2CHTR2B | |
| SCHEMBL4134736 | 0.70 | KDM1A (0.56) | KDM1AHTR2AHTR2CHTR2BSLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5889031-A | CONTROLLING CIRCADIAN RHYTHMS | BRISTOL-MYERS SQUIBB COMPNAY (US) | 1999-03-30 | — | — | US | disclosed |
| US-5753709-A | N-acyl-2 aryl cyclopropylmethylamine derivatives as melatonergics | BRISTOL-MYERS SQUIBB COMPANY (US) | 1998-05-19 | — | — | US | disclosed |