Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.60 |
| ▸ | HTR2A | P28223 | 1/20 | 0.59 |
| ▸ | CACNA1G | O43497 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.56 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.56 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.54 |
| ▸ | DRD3 | P35462 | 1/20 | 0.54 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | TDO2 | P48775 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1505913 | 0.86 | ALDH1A1 (0.75) | KDM4EALDH1A1 | |
| SCHEMBL14495108 | 0.86 | HTR2A (0.67) | HTR2ACACNA1G | |
| SCHEMBL4591716 | 0.86 | ALDH1A1 (0.67) | KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL493434 | 0.86 | MEN1 (0.61) | KDM4ECACNA1GALDH1A1SIGMAR1 | |
| SCHEMBL7851403 | 0.86 | KDM4E (0.60) | KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL2794872 | 0.85 | ALDH1A1 (0.63) | KDM4EALDH1A1SIGMAR1 | |
| SCHEMBL29241052 | 0.84 | KDM4E (0.65) | KDM4EALDH1A1 | |
| SCHEMBL25011360 | 0.83 | KDM4E (0.57) | KDM4EALDH1A1 | |
| SCHEMBL22470305 | 0.83 | POLB (0.57) | KDM4EALDH1A1 | |
| SCHEMBL31415004 | 0.83 | KDM4E (0.57) | KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9249098-B2 | Derivatives of donepezil | CHENG XUEHENG (US) | 2016-02-02 | — | — | US | disclosed |
| US-9249098-B2 | Derivatives of donepezil | CHENG XUEHENG (US) | 2016-02-02 | — | — | US | disclosed |
| US-20150225343-A1 | NOVEL DERIVATIVES OF DONEPEZIL | CHENG XUEHENG (US) | 2015-08-13 | — | — | US | disclosed |
| US-20150225343-A1 | NOVEL DERIVATIVES OF DONEPEZIL | CHENG XUEHENG (US) | 2015-08-13 | — | — | US | disclosed |
| WO-2014008629-A1 | NOVEL DERIVATIVES OF DONEPEZIL | SUZHOU SHANGZHI BIOTECH LIMITED (CN) | 2014-01-16 | — | — | WO | disclosed |
| EP-0760368-B1 | PYRIMIDINE DERIVATIVES | NISSHIN FLOUR MILLING CO (JP) | 1999-07-28 | — | — | EP | disclosed |
| US-5736550-A | TREATMENT OF GASTROINTESTINAL TRACT DISORDERS | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1998-04-07 | — | — | US | disclosed |
| EP-0760368-A1 | NOVEL PYRIMIDINE DERIVATIVE | NISSHIN FLOUR MILLING CO., LTD. (JP) | 1997-03-05 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225343-A1 | NOVEL DERIVATIVES OF DONEPEZIL | ACHE, BCHE, HNMT | KDM4E 893/4885HTR2A 474/4885CACNA1G 1104/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.