Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | CHRNB2 | P17787 | 5/20 | 0.35 |
| ▸ | CHRNA4 | P43681 | 5/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 3/20 | 0.35 |
| ▸ | CHRNA3 | P32297 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3088928 | 0.90 | ALDH1A1 (0.42) | ALOX15CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL13540974 | 0.82 | CA1 (0.39) | ALOX15CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5964962 | 0.82 | CA1 (0.42) | CHRNB2CHRNA4CHRNB4CHRNA3ALDH1A1 | |
| SCHEMBL8330887 | 0.81 | ALOX15 (0.36) | ALOX15CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL5965030 | 0.80 | MAPT (0.43) | ALOX15ALDH1A1MAPT | |
| SCHEMBL1463418 | 0.79 | ALOX15 (0.40) | ALOX15CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL14991536 | 0.78 | ALDH1A1 (0.39) | ALOX15ALDH1A1MAPT | |
| SCHEMBL222762 | 0.78 | CHRNB2 (0.57) | ALOX15CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL3666732 | 0.76 | ACE2 (0.37) | ALDH1A1 | |
| SCHEMBL4840226 | 0.75 | ALOX15 (0.58) | ALOX15CHRNB2CHRNA4CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5908858-A | OSTEOPOROSIS; LEUKOTRIENE INHIBITOR | SANKYO COMPANY, LIMITED (JP) | 1999-06-01 | — | — | US | disclosed |
| EP-0799823-A1 | 1,2-Diphenylpyrrole derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1997-10-08 | — | — | EP | disclosed |