Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 15/20 | 0.56 |
| ▸ | PTGS2 | P35354 | 13/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | GCGR | P47871 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8442548 | 0.81 | PTGS1 (0.52) | PTGS1PTGS2HTTUSP2ALDH1A1 | |
| SCHEMBL8334157 | 0.80 | MAPK14 (0.53) | PTGS1PTGS2HTTGCGR | |
| SCHEMBL8266257 | 0.77 | PTGS1 (0.67) | PTGS1PTGS2HTTUSP2ALDH1A1 | |
| SCHEMBL4614322 | 0.75 | CES2 (0.42) | PTGS1ALDH1A1 | |
| SCHEMBL7627881 | 0.73 | PTGS2 (0.61) | PTGS1PTGS2HTTALDH1A1GCGR | |
| SCHEMBL11323370 | 0.73 | CES2 (0.40) | PTGS1ALDH1A1 | |
| SCHEMBL161234 | 0.73 | CES2 (0.40) | PTGS1ALDH1A1 | |
| Ammonia Solution, Strong SCHEMBL4615643 | 0.73 | CES2 (0.40) | PTGS1ALDH1A1 | |
| SCHEMBL3822242 | 0.72 | PTGS2 (1.00) | PTGS1PTGS2 | |
| SCHEMBL8296495 | 0.72 | PTGS1 (0.64) | PTGS1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004054575-A1 | COMBINATIONS OF VALSARTAN WITH COX-2 INHIBITORS | NOVARTIS AG (CH) | 2004-07-01 | — | — | WO | disclosed |