Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHBP | P24387 | 1/20 | 0.55 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.55 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.51 |
| ▸ | CES1 | P23141 | 2/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | CES2 | O00748 | 1/20 | 0.49 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.49 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3034317 | 0.84 | MAPT (0.53) | CRHBPCRHR2TDP1MAPK1ALDH1A1 | |
| SCHEMBL11107022 | 0.84 | HDAC1 (0.45) | ALDH1A1SMN1; SMN2MAPTMEN1KMT2A | |
| SCHEMBL27884533 | 0.83 | ALDH1A1 (0.57) | CRHBPCRHR2TDP1MAPK1ALDH1A1 | |
| SCHEMBL1429530 | 0.81 | MAPK1 (0.51) | CRHBPCRHR2TDP1MAPK1ALDH1A1 | |
| SCHEMBL5114622 | 0.81 | MAPK1 (0.51) | CRHBPCRHR2TDP1MAPK1ALDH1A1 | |
| SCHEMBL380461 | 0.80 | CRHBP (0.55) | CRHBPCRHR2TDP1MAPK1ALDH1A1 | |
| SCHEMBL11441268 | 0.79 | ALDH1A1 (0.50) | CRHBPCRHR2TDP1MAPK1ALDH1A1 | |
| SCHEMBL584608 | 0.79 | MAPK1 (0.62) | CRHBPCRHR2TDP1MAPK1ALDH1A1 | |
| SCHEMBL3936910 | 0.78 | BCHE (0.50) | CRHBPCRHR2TDP1MAPK1ALDH1A1 | |
| SCHEMBL3934361 | 0.78 | CRHBP (0.49) | CRHBPCRHR2TDP1MAPK1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783318-A4 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO INC (US) | 1999-10-20 | — | — | EP | disclosed |
| EP-0783318-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO. INC. (US) | 1997-07-16 | — | — | EP | disclosed |
| US-5585359-A | LACK OF THIOL MOIETY PREVENTS THIOL-DEPENDENT CHEMICAL REACTIONS AND REDUCES SYSTEMIC TOXICITY | MERCK & CO., INC. (US) | 1996-12-17 | — | — | US | disclosed |
| WO-1996009836-A1 | INHIBITORS OF FARNESYL-PROTEIN TRANSFERASE | MERCK & CO., INC. (US) | 1996-04-04 | — | — | WO | disclosed |