Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | CRHBP | P24387 | 1/20 | 0.51 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | BCHE | P06276 | 1/20 | 0.49 |
| ▸ | ACHE | P22303 | 1/20 | 0.49 |
| ▸ | CA12 | O43570 | 1/20 | 0.49 |
| ▸ | CA9 | Q16790 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.49 |
| ▸ | CA2 | P00918 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1429530 | 0.87 | MAPK1 (0.51) | MAPK1ALDH1A1CRHBPCRHR2CES1 | |
| SCHEMBL27884533 | 0.87 | ALDH1A1 (0.57) | MAPK1ALDH1A1CRHBPCRHR2CES1 | |
| SCHEMBL11441268 | 0.86 | ALDH1A1 (0.50) | MAPK1ALDH1A1CRHBPCRHR2CES1 | |
| SCHEMBL11061489 | 0.85 | CRHBP (0.60) | MAPK1ALDH1A1CRHBPCRHR2CES1 | |
| SCHEMBL3936910 | 0.84 | BCHE (0.50) | MAPK1ALDH1A1CRHBPCRHR2CES1 | |
| SCHEMBL380461 | 0.83 | CRHBP (0.55) | MAPK1ALDH1A1CRHBPCRHR2CES1 | |
| SCHEMBL3095592 | 0.82 | LMNA (0.49) | MAPK1ALDH1A1CRHBPCRHR2MAPT | |
| SCHEMBL9184295 | 0.81 | TMEM97 (0.64) | MAPK1ALDH1A1MAPTHDAC3HDAC1 | |
| SCHEMBL8333435 | 0.81 | CRHBP (0.55) | MAPK1ALDH1A1CRHBPCRHR2CES1 | |
| SCHEMBL14776737 | 0.79 | CRHBP (0.57) | MAPK1ALDH1A1CRHBPCRHR2CES1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0819113-A1 | BENZAMIDES FOR NEURODEGENERATIVE DISORDER TREATMENT | CENTAUR PHARMACEUTICALS, INC. (US) | 1998-01-21 | — | — | EP | claimed |
| WO-1996031462-A1 | BENZAMIDES FOR NEURODEGENERATIVE DISORDER TREATMENT | CENTAUR PHARMACEUTICALS, INC. (US) | 1996-10-10 | — | — | WO | claimed |
| CN-101287736-A | Pyrrolopyrimidine derivatives as SYK inhibitors | GLAXO GROUP LTD (GB) | 2008-10-15 | — | — | CN | disclosed |
| US-20080004295-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-01-03 | — | — | US | disclosed |
| US-20080004295-A1 | NOVEL COMPOUNDS | GLAXO GROUP LIMITED (GB) | 2008-01-03 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080004295-A1 | NOVEL COMPOUNDS | SYK, BTK, LCK | MAPK1 297/4885ALDH1A1 2075/4885CRHBP 3774/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.