Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 5/20 | 0.46 |
| ▸ | RARG | P13631 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 8/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 2/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.36 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.36 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.36 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.36 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8337457 | 0.93 | PPARG (0.53) | PPARGRARGRXRAMAPTTHRB | |
| SCHEMBL2085262 | 0.79 | MAPT (0.40) | PPARGMAPTTHRBGAAALDH1A1 | |
| SCHEMBL8472017 | 0.75 | POLB (0.45) | MAPTTHRBGAAALDH1A1L3MBTL1 | |
| SCHEMBL3774754 | 0.75 | MAPT (0.50) | MAPTTHRBGAAALDH1A1POLB | |
| SCHEMBL6032173 | 0.74 | MAPT (0.54) | MAPTTHRBGAAALDH1A1L3MBTL1 | |
| SCHEMBL6891679 | 0.73 | PPARG (0.64) | PPARGRARGRXRAMAPTGAA | |
| SCHEMBL8689551 | 0.73 | POLB (0.41) | MAPTTHRBGAAALDH1A1KDM4E | |
| SCHEMBL8472109 | 0.73 | MAPT (0.42) | MAPTTHRBGAAALDH1A1PKM | |
| SCHEMBL8679131 | 0.72 | MAPT (0.41) | MAPTTHRBGAAALDH1A1KDM4E | |
| SCHEMBL8659796 | 0.72 | MAPT (0.43) | PPARGMAPTTHRBGAAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5741803-A | Substituted thiazolidinedionle derivatives | SMITHKLINE BEECHAM PLC (GB) | 1998-04-21 | — | — | US | claimed |
| US-5910592-A | STABLE, WATER SOLUBLE COMPOUNDS USED FOR TREATMENT OF TYPE IIDIABETES, ATHEROSCLEROSIS AND EATING DISORDERS | SMITHKLINE BEECHAM PLC (GB) | 1999-06-08 | — | — | US | disclosed |
| US-5741803-A | Substituted thiazolidinedionle derivatives | SMITHKLINE BEECHAM PLC (GB) | 1998-04-21 | — | — | US | disclosed |