SCHEMBL8334138

SCHEMBL8334138

Cc1ccc(C(=O)c2ccc(C(=O)c3ccc(O)cc3)cc2)cc1

nearest known ligand 0.80

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.80
LMNA P02545 3/20 0.80
MAPT P10636 4/20 0.75
HTT P42858 2/20 0.75
ESR2 Q92731 2/20 0.75
ESR1 P03372 1/20 0.75
PKM P14618 1/20 0.75
HPGD P15428 1/20 0.75
SRD5A2 P31213 3/20 0.67
ACHE P22303 1/20 0.65
SMN1; SMN2 Q16637 2/20 0.63
MAPK1 P28482 1/20 0.60
CES2 O00748 1/20 0.56
CES1 P23141 1/20 0.56
GAA P10253 1/20 0.56
RAB9A P51151 3/20 0.56
MEN1 O00255 1/20 0.56
KMT2A Q03164 1/20 0.56
POLB P06746 1/20 0.55
MAOA P21397 1/20 0.55

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1101886 1.00 ALDH1A1 (0.80) ALDH1A1LMNAMAPTHTTESR2
SCHEMBL27475874 0.93 LMNA (0.70) ALDH1A1LMNAMAPTHTTESR2
SCHEMBL25398342 0.91 RAB9A (0.70) ALDH1A1LMNAMAPTHTTESR2
SCHEMBL52200 0.89 ALDH1A1 (1.00) ALDH1A1LMNAMAPTHTTESR2
SCHEMBL822185 0.89 ALDH1A1 (1.00) ALDH1A1LMNAMAPTHTTESR2
SCHEMBL14310920 0.88 LMNA (0.61) ALDH1A1LMNAMAPTHTTESR2
SCHEMBL18678546 0.88 LMNA (0.61) ALDH1A1LMNAMAPTHTTESR2
SCHEMBL10783506 0.88 LMNA (0.61) ALDH1A1LMNAMAPTHTTESR2
SCHEMBL12300250 0.88 LMNA (0.61) ALDH1A1LMNAMAPTHTTESR2
SCHEMBL12757099 0.88 LMNA (0.61) ALDH1A1LMNAMAPTHTTESR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0809490-A4 USE OF LCK SH2 SPECIFIC COMPOUNDS TO TREAT AUTOIMMUNE DISEASES AND ALLOGRAFT REJECTION SMITHKLINE BEECHAM CORP (US) 1999-10-20 EP disclosed
EP-0871436-A4 USE OF Stat 6 SH2 DOMAIN SPECIFIC COMPOUNDS TO TREAT ALLERGIC REACTIONS SMITHKLINE BEECHAM CORP (US) 1999-10-20 EP disclosed
EP-0835104-A4 USE OF STAT 5 SH2 DOMAIN SPECIFIC COMPOUNDS TO ENHANCE ERYTHROPOIESIS SMITHKLINE BEECHAM CORP (US) 1999-10-20 EP disclosed
EP-0871436-A1 USE OF Stat 6 SH2 DOMAIN SPECIFIC COMPOUNDS TO TREAT ALLERGIC REACTIONS SMITHKLINE BEECHAM CORPORATION (US) 1998-10-21 EP disclosed
EP-0835104-A1 USE OF STAT 5 SH2 DOMAIN SPECIFIC COMPOUNDS TO ENHANCE ERYTHROPOIESIS SMITHKLINE BEECHAM CORPORATION (US) 1998-04-15 EP disclosed
EP-0809490-A1 USE OF LCK SH2 SPECIFIC COMPOUNDS TO TREAT AUTOIMMUNE DISEASES AND ALLOGRAFT REJECTION SMITHKLINE BEECHAM CORPORATION (US) 1997-12-03 EP disclosed
WO-1997002023-A1 USE OF Stat 6 SH2 DOMAIN SPECIFIC COMPOUNDS TO TREAT ALLERGIC REACTIONS SMITHKLINE BEECHAM CORPORATION (US) 1997-01-23 WO disclosed
WO-1997002024-A1 USE OF STAT 5 SH2 DOMAIN SPECIFIC COMPOUNDS TO ENHANCE ERYTHROPOIESIS SMITHKLINE BEECHAM CORPORATION (US) 1997-01-23 WO disclosed
CN-1135333-A Usage of SRCSH2 specific compound for treatment of bone absorption disease SMITHKLINE BEECHAM CORP (US) 1996-11-13 CN disclosed
EP-0728482-A2 Use of hcp specific compounds to enhance erythropoiesis SMITHKLINE BEECHAM CORPORATION (US) 1996-08-28 EP disclosed
EP-0727211-A1 Use of src SH2 specific compounds to treat a bone resorption disease SMITHKLINE BEECHAM CORPORATION (US) 1996-08-21 EP disclosed
WO-1996024343-A1 USE OF LCK SH2 SPECIFIC COMPOUNDS TO TREAT AUTOIMMUNE DISEASES AND ALLOGRAFT REJECTION SMITHKLINE BEECHAM CORPORATION (US) 1996-08-15 WO disclosed