Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CES2 | O00748 | 1/20 | 0.39 |
| ▸ | CES1 | P23141 | 1/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 1/20 | 0.39 |
| ▸ | BAD | Q92934 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 2/20 | 0.37 |
| ▸ | CA2 | P00918 | 2/20 | 0.37 |
| ▸ | MITF | O75030 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.34 |
| ▸ | MAOB | P27338 | 1/20 | 0.34 |
| ▸ | TNFRSF1A | P19438 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8331470 | 0.79 | NFE2L2 (0.43) | CES2CES1MAPTCA1CA2 | |
| SCHEMBL8334920 | 0.78 | TSHR (0.43) | CES2CES1MAPTCA1CA2 | |
| SCHEMBL2097603 | 0.77 | CES2 (0.46) | CES2CES1BCL2L1BADMAPT | |
| SCHEMBL29337015 | 0.74 | SMN1; SMN2 (0.36) | CES2CES1MAPTCA1CA2 | |
| SCHEMBL24631062 | 0.71 | SMN1; SMN2 (0.34) | CES2CES1MAPTCA1CA2 | |
| SCHEMBL12168638 | 0.68 | MAPT (0.48) | CES2CES1BCL2L1BADMAPT | |
| SCHEMBL8364930 | 0.66 | MAPT (0.73) | CES2CES1BCL2L1BADMAPT | |
| SCHEMBL27363076 | 0.66 | CES2 (0.50) | CES2CES1BCL2L1BADCA1 | |
| SCHEMBL13864066 | 0.65 | NFE2L2 (0.65) | CES2CES1BCL2L1BADMAPT | |
| SCHEMBL20846412 | 0.65 | SMN1; SMN2 (0.41) | CES2CES1BCL2L1BADMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004056787-A1 | CYCLOPENTYL GLUTARAMIDES AND THEIR USE AS NEUTRAL ENDOPEPTIDASE INHIBITORS | PFIZER LIMITED (GB) | 2004-07-08 | — | — | WO | disclosed |