Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 4/20 | 0.50 |
| ▸ | DRD2 | P14416 | 4/20 | 0.50 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | MITF | O75030 | 1/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CCND1 | P24385 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8335507 | 0.93 | SIRT2 (0.56) | HTR1ADRD2SIRT2KDRMEN1 | |
| SCHEMBL8322554 | 0.82 | SIRT2 (0.74) | HTR1ADRD2SIRT2KDRMEN1 | |
| SCHEMBL9375258 | 0.78 | SIRT2 (0.49) | HTR1ADRD2SIRT2KDRMEN1 | |
| SCHEMBL14459912 | 0.77 | HTR1A (0.44) | HTR1ADRD2SIRT2KDRMEN1 | |
| SCHEMBL7198405 | 0.76 | SIRT2 (0.60) | HTR1ASIRT2KDRMEN1LMNA | |
| SCHEMBL8323398 | 0.73 | SIRT2 (0.59) | HTR1ADRD2SIRT2KDRMEN1 | |
| SCHEMBL28101300 | 0.72 | SIRT2 (0.58) | HTR1ADRD2SIRT2KDRMEN1 | |
| SCHEMBL8354023 | 0.72 | LMNA (0.50) | HTR1ADRD2MEN1LMNAMAPT | |
| SCHEMBL31667405 | 0.71 | CASP3 (0.58) | CASP3 | |
| SCHEMBL7816070 | 0.71 | CDK4 (0.78) | SIRT2KDRMEN1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004048384-A1 | N,N-BRIDGED, NITROGEN-SUBSTITUTED CARBACYCLIC INDOLOCARBAZOLES AS PROTEIN KINASE INHIBITORS | NAD AG (DE) | 2004-06-10 | — | — | WO | disclosed |