Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 2/20 | 0.58 |
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | PARP1 | P09874 | 1/20 | 0.58 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.49 |
| ▸ | C1S | P09871 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4533433 | 0.83 | RXFP1 (0.60) | NPC1MEN1KMT2APARP1RXFP1 | |
| SCHEMBL28301105 | 0.82 | RXFP1 (0.59) | NPC1MEN1KMT2APARP1RXFP1 | |
| SCHEMBL13726555 | 0.82 | NPC1 (0.71) | NPC1MEN1KMT2ARXFP1TDP1 | |
| SCHEMBL28055395 | 0.80 | TDP1 (0.57) | NPC1MEN1KMT2APARP1RXFP1 | |
| SCHEMBL3991159 | 0.79 | RXFP1 (0.56) | NPC1MEN1KMT2APARP1RXFP1 | |
| SCHEMBL28201645 | 0.79 | LOXL2 (0.55) | MEN1KMT2ATDP1KDM4EHPGD | |
| SCHEMBL8592573 | 0.78 | L3MBTL1 (0.56) | NPC1MEN1KMT2APARP1TDP1 | |
| SCHEMBL31149717 | 0.77 | PARP1 (0.62) | NPC1MEN1KMT2APARP1RXFP1 | |
| SCHEMBL1808868 | 0.77 | PARP1 (0.62) | NPC1MEN1KMT2APARP1RXFP1 | |
| SCHEMBL12647390 | 0.77 | MEN1 (0.51) | NPC1MEN1KMT2APARP1RXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5968975-A | TREATING ATHEROSCLEROSIS | AMERICAN HOME PRODUCTS CORPORATION (US) | 1999-10-19 | — | — | US | disclosed |
| WO-1998057925-A1 | ELEVATION OF HDL CHOLESTEROL BY 2-[(AMINOTHIOXOMETHYL)-HYDRAZONO]-2-ARYLETHYL CARBAMATES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-12-23 | — | — | WO | disclosed |