Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RIPK2 | O43353 | 1/20 | 0.46 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | JAK1 | P23458 | 4/20 | 0.36 |
| ▸ | JAK3 | P52333 | 4/20 | 0.36 |
| ▸ | CDC7 | O00311 | 2/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CDK2 | P24941 | 1/20 | 0.36 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9869104 | 0.89 | MKNK1 (0.43) | JAK1JAK3MAPK14 | |
| SCHEMBL8339312 | 0.86 | CDC7 (0.43) | RIPK2LMNAKDM4EALDH1A1MAPK1 | |
| SCHEMBL8337977 | 0.86 | TLR8 (0.50) | RIPK2RAB9ASMN1; SMN2ALDH1A1JAK1 | |
| SCHEMBL8337425 | 0.83 | KDM4E (0.52) | RAB9ASMN1; SMN2KDM4EALDH1A1HPGD | |
| SCHEMBL10555321 | 0.80 | KEAP1 (0.42) | LMNAKDM4EALDH1A1MAPK14KEAP1 | |
| SCHEMBL30147332 | 0.65 | RIPK2 (0.69) | RIPK2RAB9ALMNASMN1; SMN2KDM4E | |
| SCHEMBL9728839 | 0.64 | PLAT (0.36) | RIPK2MAP2K1CLK4DYRK1BKDM4E | |
| SCHEMBL2743084 | 0.63 | RIPK2 (1.00) | RIPK2RAB9ALMNASMN1; SMN2ALDH1A1 | |
| SCHEMBL10554470 | 0.63 | — | — | |
| SCHEMBL10560055 | 0.63 | MKNK1 (0.41) | LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957918-A1 | METHOD OF TREATING OR INHIBITING NEUTROPENIA | American Cyanamid Company (US) | 1999-11-24 | — | — | EP | disclosed |
| US-5932585-A | Method of treating or inhibiting neutropenia | AMERICAN CYANAMID COMPANY (US) | 1999-08-03 | — | — | US | disclosed |
| WO-1998026781-A1 | METHOD OF TREATING OR INHIBITING NEUTROPENIA | AMERICAN CYANAMID COMPANY (US) | 1998-06-25 | — | — | WO | disclosed |
| US-5013737-A | Hypotensive, anxiolytic, cognitive disorders | AMERICAN CYANAMID COMPANY (US) | 1991-05-07 | — | — | US | disclosed |
| US-4916137-A | 5-(Substituted-amino)-8-(phenyl or substituted-phenyl)-3H,6H-1,4,5A,8A-tetraazaacenaphthylen-3-ones and treatment of neural behavior disorders | AMERICAN CYANAMID COMPANY (US) | 1990-04-10 | — | — | US | disclosed |
| EP-0329940-A1 | 5-(substituted)amino)-8- (phenyl or substituted phenyl)-3H,6H-1,2,5,a,8 a-tetraazaacenaphthylen-3-ones | AMERICAN CYANAMID COMPANY (US) | 1989-08-30 | — | — | EP | disclosed |