Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.50 |
| ▸ | CDC7 | O00311 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | JAK3 | P52333 | 2/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.36 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.35 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.35 |
| ▸ | KDM5A | P29375 | 1/20 | 0.35 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.35 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.35 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10556727 | 0.90 | TLR8 (0.40) | TLR8NPC1RAB9AKMT2ADHODH | |
| SCHEMBL8339312 | 0.86 | CDC7 (0.43) | CDC7JAK1JAK3JAK2TYK2 | |
| SCHEMBL8335601 | 0.86 | RIPK2 (0.46) | CDC7JAK1JAK3JAK2TYK2 | |
| SCHEMBL8337425 | 0.84 | KDM4E (0.52) | JAK2NPC1RAB9APARP1ALDH1A1 | |
| SCHEMBL9869104 | 0.82 | MKNK1 (0.43) | JAK1JAK3KMT2ADHODHMKNK1 | |
| SCHEMBL9870279 | 0.69 | HTT (0.40) | TLR8JAK1JAK3JAK2TYK2 | |
| SCHEMBL10554458 | 0.68 | NR4A3 (0.40) | NPC1RAB9AKMT2AKDM5AKDM4C | |
| SCHEMBL9869743 | 0.67 | KDM4E (0.50) | JAK2NPC1RAB9APARP1ALDH1A1 | |
| SCHEMBL3427893 | 0.66 | RIPK2 (0.68) | TLR8NPC1RAB9AKMT2ARIPK2 | |
| SCHEMBL8331920 | 0.66 | TLR8 (1.00) | TLR8KDM5AKDM4CKDM5BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0957918-A1 | METHOD OF TREATING OR INHIBITING NEUTROPENIA | American Cyanamid Company (US) | 1999-11-24 | — | — | EP | disclosed |
| US-5932585-A | Method of treating or inhibiting neutropenia | AMERICAN CYANAMID COMPANY (US) | 1999-08-03 | — | — | US | disclosed |
| WO-1998026781-A1 | METHOD OF TREATING OR INHIBITING NEUTROPENIA | AMERICAN CYANAMID COMPANY (US) | 1998-06-25 | — | — | WO | disclosed |
| EP-0329940-B1 | 5-(substituted)amino)-8- (phenyl or substituted phenyl)-3H,6H-1,2,5,a,8 a-tetraazaacenaphthylen-3-ones | AMERICAN CYANAMID CO (US) | 1994-01-05 | — | — | EP | disclosed |
| US-4916137-A | 5-(Substituted-amino)-8-(phenyl or substituted-phenyl)-3H,6H-1,4,5A,8A-tetraazaacenaphthylen-3-ones and treatment of neural behavior disorders | AMERICAN CYANAMID COMPANY (US) | 1990-04-10 | — | — | US | disclosed |
| EP-0329940-A1 | 5-(substituted)amino)-8- (phenyl or substituted phenyl)-3H,6H-1,2,5,a,8 a-tetraazaacenaphthylen-3-ones | AMERICAN CYANAMID COMPANY (US) | 1989-08-30 | — | — | EP | disclosed |