Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.53 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 1/20 | 0.42 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.41 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8335747 | 0.87 | HSD17B10 (0.57) | LMNAHSD17B1HSD17B10NPC1KMT2A | |
| SCHEMBL8457497 | 0.80 | MAPT (0.50) | LMNAHSD17B10ELANENPC1MAPT | |
| SCHEMBL8338448 | 0.79 | HCRTR1 (0.47) | LMNAHSD17B10NPC1KMT2AESR1 | |
| 4-Acetoxyphenol SCHEMBL11308692 | 0.76 | LMNA (0.83) | LMNAHSD17B10ELANEKMT2AMAPT | |
| SCHEMBL8460794 | 0.76 | HSD17B10 (0.56) | LMNAHSD17B10ELANENPC1KMT2A | |
| SCHEMBL8336564 | 0.76 | HSD17B10 (0.49) | LMNAHSD17B1HSD17B10NPC1KMT2A | |
| SCHEMBL9002560 | 0.75 | LMNA (0.58) | LMNAHSD17B10ELANENPC1KMT2A | |
| SCHEMBL1551126 | 0.74 | LMNA (0.87) | LMNAHSD17B10MAOBELANEKMT2A | |
| SCHEMBL8630381 | 0.74 | ESR1 (0.80) | LMNAHSD17B10KMT2AESR1MAPT | |
| SCHEMBL8460805 | 0.74 | BACE1 (0.57) | LMNAHSD17B10ELANENPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1999007694-A1 | COMPOUNDS AND USES THEREOF | ELI LILLY AND COMPANY (US) | 1999-02-18 | — | — | WO | disclosed |