SCHEMBL8336972

SCHEMBL8336972

Cc1cccc(NC(=O)C(NC(=O)OC(C)(C)C)c2ccccc2)c1

nearest known ligand 0.57

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
CTSS P25774 1/20 0.57
CTSK P43235 1/20 0.57
BACE1 P56817 4/20 0.55
HDAC4 P56524 2/20 0.49
HDAC1 Q13547 2/20 0.49
HDAC3 O15379 1/20 0.48
HDAC7 Q8WUI4 1/20 0.48
HDAC2 Q92769 1/20 0.48
HDAC10 Q969S8 1/20 0.48
HDAC11 Q96DB2 1/20 0.48
HDAC8 Q9BY41 1/20 0.48
HDAC6 Q9UBN7 1/20 0.48
HDAC9 Q9UKV0 1/20 0.48
HDAC5 Q9UQL6 1/20 0.48
ALDH1A1 P00352 2/20 0.47
KDM4E B2RXH2 1/20 0.47
MAPT P10636 1/20 0.47
TP53 P04637 1/20 0.46
S1PR3 Q99500 1/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8338471 0.90 CTSS (0.59) CTSSCTSKBACE1HDAC4HDAC1
SCHEMBL8338149 0.89 CTSK (0.66) CTSSCTSKBACE1HDAC4HDAC1
SCHEMBL31048635 0.89 CTSK (0.66) CTSSCTSKBACE1HDAC4HDAC1
SCHEMBL8336332 0.86 CTSS (0.60) CTSSCTSKBACE1HDAC8ALDH1A1
SCHEMBL8338577 0.86 CTSS (0.57) CTSSCTSKBACE1HDAC4HDAC1
SCHEMBL8337969 0.86 CTSS (0.57) CTSSCTSKBACE1HDAC4HDAC1
SCHEMBL8337364 0.85 SMN1; SMN2 (0.58) CTSSCTSKBACE1HDAC8ALDH1A1
SCHEMBL8335648 0.85 CTSS (0.54) CTSSCTSKBACE1HDAC4HDAC1
SCHEMBL8336482 0.85 SMN1; SMN2 (0.58) CTSSCTSKBACE1HDAC8ALDH1A1
SCHEMBL6715528 0.85 HSD17B10 (0.53) ALDH1A1KDM4EMAPTTP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2004022534-A1 ARYLGLYCINE DERIVATIVES FOR USE AS GLYCINE TRANSPORT INHIBITORS NPS ALLELIX CORP. (CA) 2004-03-18 WO disclosed
WO-2004022528-A2 ARYLGLYCINE DERIVATIVES AND THEIR USE AS GLYCINE TRANSPORT INHIBITORS NPS ALLELIX CORP. (CA) 2004-03-18 WO disclosed