Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 8/20 | 0.74 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.57 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.57 |
| ▸ | RECQL | P46063 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.56 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | XBP1 | P17861 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | HTT | P42858 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | GAA | P10253 | 1/20 | 0.52 |
| ▸ | PHGDH | O43175 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3712337 | 0.84 | LMNA (0.60) | LMNANPSR1SMN1; SMN2RECQLPOLB | |
| SCHEMBL31642475 | 0.78 | POLB (0.73) | LMNANPSR1CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL12781894 | 0.78 | POLB (0.73) | LMNANPSR1CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL28226906 | 0.78 | ALDH1A1 (0.77) | LMNANPSR1CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL10790246 | 0.77 | LMNA (0.58) | LMNANPSR1CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL13536326 | 0.77 | LMNA (0.59) | LMNANPSR1CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL13923614 | 0.76 | LMNA (0.67) | LMNANPSR1CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL6926448 | 0.76 | SIGMAR1 (0.64) | LMNANPSR1CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL27896818 | 0.76 | LMNA (0.71) | LMNANPSR1CYP2D6CYP2C19SMN1; SMN2 | |
| SCHEMBL6256297 | 0.75 | LMNA (0.71) | LMNANPSR1CYP2D6CYP2C19SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004018465-A9 | BENZONAPHTHYRIDINES WITH PDE 3/4 INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2005-09-15 | — | — | WO | disclosed |
| WO-2004018465-A2 | BENZONAPHTHYRIDINES WITH PDE 3/4 INHIBITING ACTIVITY | ALTANA PHARMA AG (DE) | 2004-03-04 | — | — | WO | disclosed |