Butanedione

Butanedione

SCHEMBL8338208

C=CC=O.CC(=O)C(C)=O.CCOC(C)OCC

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.48
TSHR P16473 2/20 0.32
ALDH1A1 P00352 2/20 0.32
TRPA1 O75762 1/20 0.32
GLO1 Q04760 1/20 0.31
HSD17B10 Q99714 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Acrolein SCHEMBL157907 0.89 LMNA (0.60) LMNATSHRALDH1A1TRPA1
Acrolein SCHEMBL3930769 0.87 LMNA (0.57) LMNATSHRALDH1A1TRPA1
Acrolein SCHEMBL8404934 0.86 LMNA (0.50) LMNATSHRALDH1A1TRPA1
Acrolein SCHEMBL35989 0.85 LMNA (0.55) LMNATSHRALDH1A1TRPA1
Butanedione SCHEMBL4368674 0.85 LMNA (0.67) LMNATSHRALDH1A1GLO1HSD17B10
Butanedione SCHEMBL23581203 0.84 LMNA (0.48) LMNATSHRALDH1A1GLO1HSD17B10
Propylene Glycol SCHEMBL9721324 0.82 LMNA (0.46) LMNATSHRALDH1A1TRPA1
1,3-Propanediol SCHEMBL8401501 0.82 LMNA (0.46) LMNATSHRALDH1A1TRPA1
Glycerin SCHEMBL842187 0.81 LMNA (0.44) LMNAALDH1A1
Methylglyoxal SCHEMBL9148515 0.79 LMNA (0.57) LMNAALDH1A1GLO1HSD17B10

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5969150-A FLUORESCENT COMPOUNDS FOR MEDICAL DIAGNOSIS, DRUGS AND LABELS OR FUNGICIDES AND VIRICIDES THE ROCKEFELLER UNIVERSITY (US) 1999-10-19 US disclosed