SCHEMBL8338270

SCHEMBL8338270

COc1ccc(-c2ccc(C)cc2)cc1C

nearest known ligand 0.52

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ACHE P22303 2/20 0.52
PDGFRB P09619 2/20 0.51
PDGFRA P16234 2/20 0.51
MAPT P10636 3/20 0.47
KDM4E B2RXH2 2/20 0.47
ALDH1A1 P00352 3/20 0.47
CYP3A4 P08684 2/20 0.47
FFAR1 O14842 1/20 0.46
PTGS2 P35354 2/20 0.44
HPGD P15428 2/20 0.44
TSHR P16473 1/20 0.43
HSD17B10 Q99714 1/20 0.43
TDP1 Q9NUW8 1/20 0.43
PTGS1 P23219 1/20 0.43
GAA P10253 1/20 0.41
ALKBH3 Q96Q83 1/20 0.41
RORC P51449 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12326161 0.91 PDGFRB (0.58) ACHEPDGFRBPDGFRAMAPTKDM4E
SCHEMBL8264357 0.85 KDM4E (0.54) PDGFRBPDGFRAMAPTKDM4EALDH1A1
SCHEMBL14499448 0.85 PDGFRB (0.50) ACHEPDGFRBPDGFRAMAPTKDM4E
SCHEMBL15342387 0.85 DYRK1A (0.52) ACHEPDGFRBPDGFRAMAPTKDM4E
SCHEMBL1912033 0.85 DYRK1A (0.52) ACHEPDGFRBPDGFRAMAPTKDM4E
SCHEMBL29644376 0.85 KDM4E (0.54) PDGFRBPDGFRAMAPTKDM4EALDH1A1
SCHEMBL12333997 0.84 ACHE (0.67) ACHEPDGFRBPDGFRAMAPTKDM4E
SCHEMBL15342384 0.84 PDGFRB (0.57) ACHEPDGFRBPDGFRAMAPTKDM4E
SCHEMBL8401018 0.84 PDGFRB (0.53) ACHEPDGFRBPDGFRAMAPTKDM4E
SCHEMBL31042563 0.84 ACHE (0.67) ACHEPDGFRBPDGFRAMAPTKDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2020121979-A1 LIQUID-CRYSTAL ALIGNMENT AGENT, LIQUID-CRYSTAL ALIGNMENT FILM, AND LIQUID-CRYSTAL DISPLAY ELEMENT 日産化学株式会社 2020-06-18 WO disclosed
WO-2019189632-A1 LIQUID CRYSTAL ALIGNMENT AGENT, LIQUID CRYSTAL ALIGNMENT FILM, AND LIQUID CRYSTAL DISPLAY ELEMENT 日産化学株式会社 2019-10-03 WO disclosed
WO-2019181878-A1 LIQUID CRYSTAL ALIGNING AGENT, LIQUID CRYSTAL ALIGNMENT FILM AND LIQUID CRYSTAL DISPLAY ELEMENT 日産化学株式会社 2019-09-26 WO disclosed
US-20120232242-A1 THIAZOLOTHIAZOLE COMPOUND AND THIAZOLOTHIAZOLE POLYMER FUJI XEROX CO., LTD. (JP) 2012-09-13 US disclosed
US-8264140-B2 Organic electroluminescence element and display device FUJI XEROX CO., LTD. (JP) 2012-09-11 US disclosed
US-8264140-B2 Organic electroluminescence element and display device FUJI XEROX CO., LTD. (JP) 2012-09-11 US disclosed
US-8207348-B2 Thiazolothiazole compound and thiazolothiazole polymer FUJI XEROX CO., LTD. (JP) 2012-06-26 US disclosed
US-20110086999-A1 THIAZOLOTHIAZOLE COMPOUND AND THIAZOLOTHIAZOLE POLYMER FUJI XEROX CO., LTD. (JP) 2011-04-14 US disclosed
US-7910748-B2 Thiophene-containing compound and thiophene-containing compound polymer, organic electroluminescent device, production method thereof, and image display medium FUJI XEROX CO., LTD. (JP) 2011-03-22 US disclosed
US-7910748-B2 Thiophene-containing compound and thiophene-containing compound polymer, organic electroluminescent device, production method thereof, and image display medium FUJI XEROX CO., LTD. (JP) 2011-03-22 US disclosed
US-7659410-B2 Thiophene-containing compound and thiophene-containing compound polymer, organic electroluminescent device, production method thereof, and image display medium FUJI XEROX CO., LTD. (JP) 2010-02-09 US disclosed
WO-2009032249-A1 SOLUBLE GUANYLATE CYCLASE ACTIVATORS MERCK & CO., INC. (US) 2009-03-12 WO disclosed
US-20090039774-A1 ORGANIC ELECTROLUMINESCENCE ELEMENT AND DISPLAY DEVICE FUJI XEROX CO., LTD. (JP) 2009-02-12 US disclosed
US-20090039774-A1 ORGANIC ELECTROLUMINESCENCE ELEMENT AND DISPLAY DEVICE FUJI XEROX CO., LTD. (JP) 2009-02-12 US disclosed
US-20080312453-A1 Novel Carbazole Compound, and Polymer Thereof FUJI XEROX CO., LTD. (JP) 2008-12-18 US disclosed
US-20080312453-A1 Novel Carbazole Compound, and Polymer Thereof FUJI XEROX CO., LTD. (JP) 2008-12-18 US disclosed
US-20070252519-A1 Novel thiophene-containing compound and thiophene-containing compound polymer, organic electroluminescent device, production method thereof, and image display medium FUJI XEROX CO., LTD. (JP) 2007-11-01 US disclosed
US-20070252519-A1 Novel thiophene-containing compound and thiophene-containing compound polymer, organic electroluminescent device, production method thereof, and image display medium FUJI XEROX CO., LTD. (JP) 2007-11-01 US disclosed
US-20070149570-A1 Piperidine derivative and use thereof TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) 2007-06-28 US disclosed
WO-2004024060-A2 METALLOPROTEINASE INHIBITORS AND INTERMEDIATES FOR PREPARATION THEREOF ASTRAZENECA AB (SE) 2004-03-25 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20070149570-A1 Piperidine derivative and use thereof TACR1, OPRL1, TRPV1 ACHE 1067/4885PDGFRB 239/4885PDGFRA 240/4885
US-20080312453-A1 Novel Carbazole Compound, and Polymer Thereof ARL1, CDKL1, PARP11 ACHE 3869/4885PDGFRB 1986/4885PDGFRA 2158/4885
US-20070252519-A1 Novel thiophene-containing compound and thiophene-containing compound polymer, organic electroluminescent device, production method thereof, and image display medium ARL1, NOD1, NLRP1 ACHE 3187/4885PDGFRB 3717/4885PDGFRA 4028/4885
US-20110086999-A1 THIAZOLOTHIAZOLE COMPOUND AND THIAZOLOTHIAZOLE POLYMER ARL1, IRAK1, TYK2 ACHE 4384/4885PDGFRB 1315/4885PDGFRA 1513/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.